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http://purl.uniprot.org/citations/22666399http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22666399http://www.w3.org/2000/01/rdf-schema#comment"

Background

Non-Hodgkin's lymphoma (NHL) has been reported to be associated with autoimmune and pro-inflammatory response, and genetic polymorphisms of candidate genes involved in autoimmune and pro-inflammatory response may influence the susceptibility to NHL. To evaluate the role of such genetic variations in risk of NHL, we conducted a case-control study of 514 NHL patients and 557 cancer-free controls in a Chinese population.

Method

We used the Taqman assay to genotype six potentially functional single nucleotide polymorphisms (SNPs) in six previously reported inflammation and immune-related genes (TNF rs1799964T>C, LTA rs1800683G>A, IL-10 rs1800872T>G, LEP rs2167270G>A, LEPR rs1327118C>G, TNFAIP8 rs1045241C>T). Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI).

Results

We observed a significantly increased risk of NHL associated with the TNFAIP8 rs1045241C>T polymorphism (adjusted OR = 3.03; 95% CI = 1.68-5.45 for TT vs. CC and adjusted OR = 2.03; 95% CI = 1.53-2.69 for CT/TT vs. CC). The risk associated with the T allele was more evident in subgroups of 40-60 year-old, non-smokers or light-smokers (less than 25 pack-years), and subjects with normal weight or overweight. Risk for both B and T cell non-Hodgkin's lymphoma was elevated for CT/TT genotypes (adjusted OR = 1.95, 95% CI = 1.41-2.70 for B cell NHL and adjusted OR = 2.22, 95% CI = 1.49-3.30 for T cell NHL), particularly for DLBCL (adjusted OR = 2.01, 95%CI = 1.41-2.85) and FL (adjusted OR = 2.53, 95% CI = 1.17-5.45). These risks were not observed for variant genotypes of other five SNPs compared with their common homozygous genotypes.

Conclusions

The polymorphism of TNFAIP8 rs1045241C>T may contribute to NHL susceptibility in a Chinese population. Further large-scale and well-designed studies are needed to confirm these results."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0037846"xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/author"He J."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/author"Jin L."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/author"Chen Z.Y."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/author"Ma X.J."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/author"Wang M.Y."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/author"Zhang Y."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/author"Wang J.C."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/author"Sun M.H."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/author"Yang Y.J."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/author"Zhou X.Y."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/author"Wei Q.Y."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/author"Hong X.N."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/author"Xia K.Q."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/name"PLoS One"xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/pages"e37846"xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/title"Tumor necrosis factor-alpha induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study."xsd:string
http://purl.uniprot.org/citations/22666399http://purl.uniprot.org/core/volume"7"xsd:string
http://purl.uniprot.org/citations/22666399http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22666399
http://purl.uniprot.org/citations/22666399http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22666399
http://purl.uniprot.org/uniprot/#_B3KUI2-mappedCitation-22666399http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22666399
http://purl.uniprot.org/uniprot/#_O95379-mappedCitation-22666399http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22666399
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