| http://purl.uniprot.org/citations/22666429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22666429 | http://www.w3.org/2000/01/rdf-schema#comment | "Alternative splicing is a fundamental posttranscriptional mechanism for controlling gene expression, and splicing defects have been linked to various human disorders. The splicing factor FOX-2 is part of a main protein interaction hub in a network related to human inherited ataxias, however, its impact remains to be elucidated. Here, we focused on the reported interaction between FOX-2 and ataxin-1, the disease-causing protein in spinocerebellar ataxia type 1. In this line, we further evaluated this interaction by yeast-2-hybrid analyses and co-immunoprecipitation experiments in mammalian cells. Interestingly, we discovered that FOX-2 localization and splicing activity is affected in the presence of nuclear ataxin-1 inclusions. Moreover, we observed that FOX-2 directly interacts with ataxin-2, a protein modulating spinocerebellar ataxia type 1 pathogenesis. Finally, we provide evidence that splicing of pre-mRNA of ataxin-2 depends on FOX-2 activity, since reduction of FOX-2 levels led to increased skipping of exon 18 in ataxin-2 transcripts. Most striking, we observed that ataxin-1 overexpression has an effect on this splicing event as well. Thus, our results demonstrate that FOX-2 is involved in splicing of ataxin-2 transcripts and that this splicing event is altered by overexpression of ataxin-1."xsd:string |
| http://purl.uniprot.org/citations/22666429 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0037985"xsd:string |
| http://purl.uniprot.org/citations/22666429 | http://purl.uniprot.org/core/author | "Lehrach H."xsd:string |
| http://purl.uniprot.org/citations/22666429 | http://purl.uniprot.org/core/author | "Kaehler C."xsd:string |
| http://purl.uniprot.org/citations/22666429 | http://purl.uniprot.org/core/author | "Krobitsch S."xsd:string |
| http://purl.uniprot.org/citations/22666429 | http://purl.uniprot.org/core/author | "Isau M."xsd:string |
| http://purl.uniprot.org/citations/22666429 | http://purl.uniprot.org/core/author | "Hallen L."xsd:string |
| http://purl.uniprot.org/citations/22666429 | http://purl.uniprot.org/core/author | "Welzel F."xsd:string |
| http://purl.uniprot.org/citations/22666429 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22666429 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22666429 | http://purl.uniprot.org/core/pages | "e37985"xsd:string |
| http://purl.uniprot.org/citations/22666429 | http://purl.uniprot.org/core/title | "FOX-2 dependent splicing of ataxin-2 transcript is affected by ataxin-1 overexpression."xsd:string |
| http://purl.uniprot.org/citations/22666429 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22666429 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22666429 |
| http://purl.uniprot.org/citations/22666429 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22666429 |
| http://purl.uniprot.org/uniprot/#_P54253-mappedCitation-22666429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22666429 |
| http://purl.uniprot.org/uniprot/#_O43251-mappedCitation-22666429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22666429 |
| http://purl.uniprot.org/uniprot/#_D2CTA3-mappedCitation-22666429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22666429 |
| http://purl.uniprot.org/uniprot/#_D2CTA5-mappedCitation-22666429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22666429 |
| http://purl.uniprot.org/uniprot/#_D2CTA6-mappedCitation-22666429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22666429 |
| http://purl.uniprot.org/uniprot/#_D2CTA7-mappedCitation-22666429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22666429 |
| http://purl.uniprot.org/uniprot/#_D2CTB1-mappedCitation-22666429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22666429 |
| http://purl.uniprot.org/uniprot/#_D2CTB2-mappedCitation-22666429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22666429 |
| http://purl.uniprot.org/uniprot/#_D2CTB3-mappedCitation-22666429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22666429 |