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http://purl.uniprot.org/citations/22668815http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22668815http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The aim of this study was to explore the association between polymorphisms in Wnt antagonist genes and bone response to hormone therapy (HT) in postmenopausal Korean women.

Methods

A prospective study was conducted with 303 postmenopausal women receiving sequential estrogen plus progestogen therapy in a university hospital. The dickkopf (Dkk) 1 c.318A>G, Dkk2 c.437G>A, Dkk3 c.1003A>G, secreted frizzled-related protein (sFRP) 1 rs3242C>T, rs16890444C>T, sFRP3 c.970C>G, sFRP4 c.958C>A, c.1019G>A, and sFRP5 c.20G>C polymorphisms were analyzed, and bone mineral density (BMD) at the lumbar spine and femoral neck (FN) was measured before and after 1 year of sequential estrogen plus progestogen therapy.

Results

The percentage changes in BMD of the FN after 1 year of HT were found to be significantly (P < 0.05) different according to the haplotype genotype composed of the sFRP4 c.958C>A and c.1019G>A polymorphisms after adjustment for baseline BMD. The percentage change in BMD at the FN after 1 year of HT was significantly higher in the AA/AG haplotype genotype than in the AG/CG (P < 0.01) or CG/CG (P < 0.05) haplotype genotype. However, any single and combined polymorphisms measured were not related with nonresponsiveness to HT when a nonresponder was defined as a woman who had lost more than 3% of BMD per year after HT.

Conclusions

The haplotype genotypes of sFRP4 c.958C>A and c.1019G>A polymorphisms are genetic factors that affect changes in BMD of the FN after HT in postmenopausal Korean women."xsd:string
http://purl.uniprot.org/citations/22668815http://purl.org/dc/terms/identifier"doi:10.1097/gme.0b013e3182503d47"xsd:string
http://purl.uniprot.org/citations/22668815http://purl.uniprot.org/core/author"Kim J.H."xsd:string
http://purl.uniprot.org/citations/22668815http://purl.uniprot.org/core/author"Kim H."xsd:string
http://purl.uniprot.org/citations/22668815http://purl.uniprot.org/core/author"Kim S.H."xsd:string
http://purl.uniprot.org/citations/22668815http://purl.uniprot.org/core/author"Kim J.G."xsd:string
http://purl.uniprot.org/citations/22668815http://purl.uniprot.org/core/author"Ku S.Y."xsd:string
http://purl.uniprot.org/citations/22668815http://purl.uniprot.org/core/author"Lee D.O."xsd:string
http://purl.uniprot.org/citations/22668815http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22668815http://purl.uniprot.org/core/name"Menopause"xsd:string
http://purl.uniprot.org/citations/22668815http://purl.uniprot.org/core/pages"1008-1014"xsd:string
http://purl.uniprot.org/citations/22668815http://purl.uniprot.org/core/title"The association between polymorphisms in Wnt antagonist genes and bone response to hormone therapy in postmenopausal Korean women."xsd:string
http://purl.uniprot.org/citations/22668815http://purl.uniprot.org/core/volume"19"xsd:string
http://purl.uniprot.org/citations/22668815http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22668815
http://purl.uniprot.org/citations/22668815http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22668815
http://purl.uniprot.org/uniprot/#_B4E1T4-mappedCitation-22668815http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22668815
http://purl.uniprot.org/uniprot/#_Q6FHJ7-mappedCitation-22668815http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22668815
http://purl.uniprot.org/uniprot/B4E1T4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22668815
http://purl.uniprot.org/uniprot/Q6FHJ7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22668815