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http://purl.uniprot.org/citations/22671039http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22671039http://www.w3.org/2000/01/rdf-schema#comment"

Background

Fetal neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening bleeding disorder in the fetus or neonate caused by maternal alloantibodies directed against fetal platelet (PLT) antigens inherited from the father. The immune-dominant antigen leading to severe FNAIT is the human PLT antigen (HPA)-1, whose polymorphism constitutes an epitope for human leukocyte antigens (HLAs), usually DRB3*0101 leading to an immune response.

Study design and methods

In this study our aims were to find whether other allele variants of the β subunit of the HLA-DR family specifically focused on the HLA residues that bind Position 33 of the HPA-1 integrin contribute to FNAIT development and affect response to treatment and whether coexistence of both anti-HPA-1a and anti-HLA class I specific against the father's antigens leads to a more severe thrombocytopenia in the newborn. We examine the genotype of 23 mothers to newborns with FNAIT compared to a control group.

Results

Our results suggested that, when HPA-1 incompatibility with the husband is found, the presence of two HLA alleles (DRB3*01:01 and DRB4*01:01) in the mother increases the risk and severity of FNAIT and reduces the success of a preventive immunoglobulin G treatment. We provide a structural model for the molecular basis of the rational effects of the different HLA alleles. In addition, we found that the presence of both anti-HPA-1 and anti-HLAs did not aggravate FNAIT in comparison to mothers harboring only anti-HPA-1.

Conclusion

Overall, we suggest that a specific genotyping of the mother in relation to HLA-DRB as well as HPA-1 can serve as an antenatal diagnostic tool, particularly in siblings of women who gave birth to neonates with FNAIT."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.org/dc/terms/identifier"doi:10.1111/j.1537-2995.2012.03734.x"xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/author"Gazit E."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/author"Landau M."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/author"Frenkel O."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/author"Rosenberg N."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/author"Yahalom V."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/author"Dardik R."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/author"Salomon O."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/author"Steinberg D.M."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/author"Kalt R."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/author"Loewenthal R."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/author"Avishai O."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/author"Lipitz S."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/name"Transfusion"xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/pages"344-352"xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/title"Compound heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia."xsd:string
http://purl.uniprot.org/citations/22671039http://purl.uniprot.org/core/volume"53"xsd:string
http://purl.uniprot.org/citations/22671039http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22671039
http://purl.uniprot.org/citations/22671039http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22671039
http://purl.uniprot.org/uniprot/#_A0A0P1GKP1-mappedCitation-22671039http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22671039
http://purl.uniprot.org/uniprot/#_A0A0P1GLA1-mappedCitation-22671039http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22671039
http://purl.uniprot.org/uniprot/#_A0A0P1JEH2-mappedCitation-22671039http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22671039
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