| http://purl.uniprot.org/citations/22675024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22675024 | http://www.w3.org/2000/01/rdf-schema#comment | "COPII-coated buds are formed at endoplasmic reticulum exit sites (ERES) to mediate ER-to-Golgi transport. Sec16 is an essential factor in ERES formation, as well as in COPII-mediated traffic in vivo. Sec16 interacts with multiple COPII proteins, although the functional significance of these interactions remains unknown. Here we present evidence that full-length Sec16 plays an important role in regulating Sar1 GTPase activity at the late steps of COPII vesicle formation. We show that Sec16 interacts with Sec23 and Sar1 through its C-terminal conserved region and hinders the ability of Sec31 to stimulate Sec23 GAP activity toward Sar1. We also find that purified Sec16 alone can self-assemble into homo-oligomeric complexes on a planar lipid membrane. These features ensure prolonged COPII coat association within a preformed Sec16 cluster, which may lead to the formation of ERES. Our results indicate a mechanistic relationship between COPII coat assembly and ERES formation."xsd:string |
| http://purl.uniprot.org/citations/22675024 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e12-05-0356"xsd:string |
| http://purl.uniprot.org/citations/22675024 | http://purl.uniprot.org/core/author | "Sato K."xsd:string |
| http://purl.uniprot.org/citations/22675024 | http://purl.uniprot.org/core/author | "Yorimitsu T."xsd:string |
| http://purl.uniprot.org/citations/22675024 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22675024 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/22675024 | http://purl.uniprot.org/core/pages | "2930-2942"xsd:string |
| http://purl.uniprot.org/citations/22675024 | http://purl.uniprot.org/core/title | "Insights into structural and regulatory roles of Sec16 in COPII vesicle formation at ER exit sites."xsd:string |
| http://purl.uniprot.org/citations/22675024 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/22675024 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22675024 |
| http://purl.uniprot.org/citations/22675024 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22675024 |
| http://purl.uniprot.org/uniprot/P48415#attribution-1D02536783F2C8C12E11FBFCB4ECFDD9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22675024 |
| http://purl.uniprot.org/uniprot/P48415#attribution-E54E1D7FD3687DE51FB505A1237F3104 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22675024 |
| http://purl.uniprot.org/uniprot/P20606#attribution-E54E1D7FD3687DE51FB505A1237F3104 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22675024 |
| http://purl.uniprot.org/uniprot/#_P13987-mappedCitation-22675024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22675024 |
| http://purl.uniprot.org/uniprot/#_P15303-mappedCitation-22675024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22675024 |
| http://purl.uniprot.org/uniprot/#_P15328-mappedCitation-22675024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22675024 |
| http://purl.uniprot.org/uniprot/#_P53992-mappedCitation-22675024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22675024 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BU54-mappedCitation-22675024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22675024 |
| http://purl.uniprot.org/uniprot/#_O14653-mappedCitation-22675024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22675024 |
| http://purl.uniprot.org/uniprot/#_P01135-mappedCitation-22675024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22675024 |
| http://purl.uniprot.org/uniprot/#_P38968-mappedCitation-22675024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22675024 |
| http://purl.uniprot.org/uniprot/#_Q13190-mappedCitation-22675024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22675024 |
| http://purl.uniprot.org/uniprot/#_Q15363-mappedCitation-22675024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22675024 |