| http://purl.uniprot.org/citations/22675480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22675480 | http://www.w3.org/2000/01/rdf-schema#comment | "Reduction of excitatory currents onto GABAergic interneurons in the forebrain results in impaired spatial working memory and altered oscillatory network patterns in the hippocampus. Whether this phenotype is caused by an alteration in hippocampal interneurons is not known because most studies employed genetic manipulations affecting several brain regions. Here we performed viral injections in genetically modified mice to ablate the GluA4 subunit of the AMPA receptor in the hippocampus (GluA4(HC-/-) mice), thereby selectively reducing AMPA receptor-mediated currents onto a subgroup of hippocampal interneurons expressing GluA4. This regionally selective manipulation led to a strong spatial working memory deficit while leaving reference memory unaffected. Ripples (125-250 Hz) in the CA1 region of GluA4(HC-/-) mice had larger amplitude, slower frequency and reduced rate of occurrence. These changes were associated with an increased firing rate of pyramidal cells during ripples. The spatial selectivity of hippocampal pyramidal cells was comparable to that of controls in many respects when assessed during open field exploration and zigzag maze running. However, GluA4 ablation caused altered modulation of firing rate by theta oscillations in both interneurons and pyramidal cells. Moreover, the correlation between the theta firing phase of pyramidal cells and position was weaker in GluA4(HC-/-) mice. These results establish the involvement of AMPA receptor-mediated currents onto hippocampal interneurons for ripples and theta oscillations, and highlight potential cellular and network alterations that could account for the altered working memory performance."xsd:string |
| http://purl.uniprot.org/citations/22675480 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0037318"xsd:string |
| http://purl.uniprot.org/citations/22675480 | http://purl.uniprot.org/core/author | "Allen K."xsd:string |
| http://purl.uniprot.org/citations/22675480 | http://purl.uniprot.org/core/author | "Monyer H."xsd:string |
| http://purl.uniprot.org/citations/22675480 | http://purl.uniprot.org/core/author | "Caputi A."xsd:string |
| http://purl.uniprot.org/citations/22675480 | http://purl.uniprot.org/core/author | "Fuchs E.C."xsd:string |
| http://purl.uniprot.org/citations/22675480 | http://purl.uniprot.org/core/author | "Le Magueresse C."xsd:string |
| http://purl.uniprot.org/citations/22675480 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22675480 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22675480 | http://purl.uniprot.org/core/pages | "e37318"xsd:string |
| http://purl.uniprot.org/citations/22675480 | http://purl.uniprot.org/core/title | "Selective reduction of AMPA currents onto hippocampal interneurons impairs network oscillatory activity."xsd:string |
| http://purl.uniprot.org/citations/22675480 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22675480 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22675480 |
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