| http://purl.uniprot.org/citations/22677173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22677173 | http://www.w3.org/2000/01/rdf-schema#comment | "Although SPE-39 is a binding protein to Vps33B that is one of the subunit in the mammalian HOPS complex, the elements of SPE-39 function remain unknown. Here, we show that tyrosine phosphorylation of SPE-39 following EGF stimulation plays a role in the stability of SPE-39 itself. Ubiquitination of the C-terminal region of SPE-39 was also elevated in response to EGF stimulation, and this process was regulated by the phosphorylation of Tyr-11 in SPE-39. However, association of Vps33B with SPE-39 inhibited the elevation of ubiquitination of SPE-39 following EGF stimulation, which might be responsible for the stabilization of SPE-39. Furthermore, an opposing functional relationship between SPE-39 and Vps33B on the downregulation of the EGF receptor was observed in EGF-stimulated COS-7 cells."xsd:string |
| http://purl.uniprot.org/citations/22677173 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.05.051"xsd:string |
| http://purl.uniprot.org/citations/22677173 | http://purl.uniprot.org/core/author | "Ohta T."xsd:string |
| http://purl.uniprot.org/citations/22677173 | http://purl.uniprot.org/core/author | "Ishii A."xsd:string |
| http://purl.uniprot.org/citations/22677173 | http://purl.uniprot.org/core/author | "Kido H."xsd:string |
| http://purl.uniprot.org/citations/22677173 | http://purl.uniprot.org/core/author | "Konishi H."xsd:string |
| http://purl.uniprot.org/citations/22677173 | http://purl.uniprot.org/core/author | "Hiyoshi M."xsd:string |
| http://purl.uniprot.org/citations/22677173 | http://purl.uniprot.org/core/author | "Kamimori K."xsd:string |
| http://purl.uniprot.org/citations/22677173 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22677173 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/22677173 | http://purl.uniprot.org/core/pages | "2245-2250"xsd:string |
| http://purl.uniprot.org/citations/22677173 | http://purl.uniprot.org/core/title | "Inhibitory effect of SPE-39 due to tyrosine phosphorylation and ubiquitination on the function of Vps33B in the EGF-stimulated cells."xsd:string |
| http://purl.uniprot.org/citations/22677173 | http://purl.uniprot.org/core/volume | "586"xsd:string |
| http://purl.uniprot.org/citations/22677173 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22677173 |
| http://purl.uniprot.org/citations/22677173 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22677173 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z555-mappedCitation-22677173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22677173 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z577-mappedCitation-22677173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22677173 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z589-mappedCitation-22677173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22677173 |
| http://purl.uniprot.org/uniprot/#_B7Z1N4-mappedCitation-22677173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22677173 |
| http://purl.uniprot.org/uniprot/#_B7Z6M7-mappedCitation-22677173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22677173 |
| http://purl.uniprot.org/uniprot/#_B4DMB7-mappedCitation-22677173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22677173 |
| http://purl.uniprot.org/uniprot/#_P01133-mappedCitation-22677173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22677173 |
| http://purl.uniprot.org/uniprot/#_F5H008-mappedCitation-22677173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22677173 |
| http://purl.uniprot.org/uniprot/#_P00533-mappedCitation-22677173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22677173 |