http://purl.uniprot.org/citations/22678798 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/22678798 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo investigate the value of a disintegrin and metalloproteinase 12 secreting form (ADAM12-S) as a maternal serum marker in second trimester screening for trisomy 21 (Down syndrome, DS), and to develop an appropriate prenatal DS screening protocol.MethodsSerum samples were collected from 53 pregnant women carrying a trisomy 21 fetus and 621 pregnant women with matched gestational age and weight carrying a healthy fetus. ADAM12-S concentrations were determined with a time-resolved fluorescence immunoassay (TRFIA). Curve fitting by weighted regression and other statistical methods were conducted, and the model was optimized for prenatal trisomy 21 screening program in second trimester. ADAM12-S alone or in combination with other two- or three-combination test was selected as a serum marker for prenatal second-trimester screening of trisomy 21 by calculation of detection rate (DR) and false positive rate (FPR).ResultsBy comparison, the median multiple of the median (MoM) value of ADAM12-S in DS pregnancy group was higher than that of the control group (P< 0.01). When FPR = 5%, the DR of ADAM12-S was 28.3%, and the positive and negative likelihood ratios were 5.66 and 0.75, respectively. The DR of three-combination test of ADAM12-S, alpha-fetoprotein (AFP) and free beta subunit of human chorionic gonadotropin (β-HCG) has increased to 52.80% from 39.62% of the conventional two-combination test (AFP and free β-HCG). For women with a risk between 1/300 and 1/1000 by two-combination test for DS, the DR has increased from 39.62% to 47.12%, but FPR only increased by 0.8% after adding ADAM12-S as a maternal serum marker.ConclusionConsidering the increased DR of pregnancies with a risk between 1/300 and 1/1000 in second trimester, ADAM12-S may provide a feasible maternal serum maker when combined with AFP and free β-HCG. The cost-effectiveness ratio is reasonable."xsd:string |
http://purl.uniprot.org/citations/22678798 | http://purl.org/dc/terms/identifier | "doi:10.3760/cma.j.issn.1003-9406.2012.03.015"xsd:string |
http://purl.uniprot.org/citations/22678798 | http://purl.uniprot.org/core/author | "Jiang T."xsd:string |
http://purl.uniprot.org/citations/22678798 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
http://purl.uniprot.org/citations/22678798 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
http://purl.uniprot.org/citations/22678798 | http://purl.uniprot.org/core/author | "Zhang X.J."xsd:string |
http://purl.uniprot.org/citations/22678798 | http://purl.uniprot.org/core/author | "Sun Y.J."xsd:string |
http://purl.uniprot.org/citations/22678798 | http://purl.uniprot.org/core/author | "Lv L."xsd:string |
http://purl.uniprot.org/citations/22678798 | http://purl.uniprot.org/core/author | "Xu Z.F."xsd:string |
http://purl.uniprot.org/citations/22678798 | http://purl.uniprot.org/core/author | "Xu Q.J."xsd:string |
http://purl.uniprot.org/citations/22678798 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
http://purl.uniprot.org/citations/22678798 | http://purl.uniprot.org/core/name | "Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string |
http://purl.uniprot.org/citations/22678798 | http://purl.uniprot.org/core/pages | "314-318"xsd:string |
http://purl.uniprot.org/citations/22678798 | http://purl.uniprot.org/core/title | "[Second trimester screening for trisomy 21 using ADAM12-S as a maternal serum marker]."xsd:string |
http://purl.uniprot.org/citations/22678798 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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