| http://purl.uniprot.org/citations/22679284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22679284 | http://www.w3.org/2000/01/rdf-schema#comment | "Patched (Ptc), the main receptor for Sonic Hedgehog, is a tumor suppressor. Ptc has been shown to be a dependence receptor, and as such triggers apoptosis in the absence of its ligand. This apoptosis induction occurs through the recruitment by the Ptc intracellular domain of a caspase-activating complex, which includes the adaptor proteins DRAL and TUCAN, and the apical caspase-9. We show here that this caspase-activating complex also includes the E3 ubiquitin ligase NEDD4. We demonstrate that Ptc-mediated apoptosis and Ptc-induced caspase-9 activation require NEDD4. We show that Ptc, but not Bax, the prototypical inducer of the intrinsic cell-death pathway, triggers polyubiquitination of caspase-9. Moreover, a caspase-9 mutant that could not be ubiquitinated failed to mediate Ptc-induced apoptosis. Taken together, these data support the view that the Ptc dependence receptor specifically allows the activation of caspase-9 via its ubiquitination, which occurs via the recruitment by Ptc of NEDD4."xsd:string |
| http://purl.uniprot.org/citations/22679284 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1200094109"xsd:string |
| http://purl.uniprot.org/citations/22679284 | http://purl.uniprot.org/core/author | "Sadoul R."xsd:string |
| http://purl.uniprot.org/citations/22679284 | http://purl.uniprot.org/core/author | "Mehlen P."xsd:string |
| http://purl.uniprot.org/citations/22679284 | http://purl.uniprot.org/core/author | "Guix C."xsd:string |
| http://purl.uniprot.org/citations/22679284 | http://purl.uniprot.org/core/author | "Fombonne J."xsd:string |
| http://purl.uniprot.org/citations/22679284 | http://purl.uniprot.org/core/author | "Thibert C."xsd:string |
| http://purl.uniprot.org/citations/22679284 | http://purl.uniprot.org/core/author | "Bissey P.A."xsd:string |
| http://purl.uniprot.org/citations/22679284 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22679284 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/22679284 | http://purl.uniprot.org/core/pages | "10510-10515"xsd:string |
| http://purl.uniprot.org/citations/22679284 | http://purl.uniprot.org/core/title | "Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9."xsd:string |
| http://purl.uniprot.org/citations/22679284 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/22679284 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22679284 |
| http://purl.uniprot.org/citations/22679284 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22679284 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVW7-mappedCitation-22679284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22679284 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-22679284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22679284 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWC4-mappedCitation-22679284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22679284 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ4-mappedCitation-22679284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22679284 |
| http://purl.uniprot.org/uniprot/#_A0A571BDN7-mappedCitation-22679284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22679284 |
| http://purl.uniprot.org/uniprot/#_A0A571BEP7-mappedCitation-22679284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22679284 |
| http://purl.uniprot.org/uniprot/#_A2AS92-mappedCitation-22679284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22679284 |
| http://purl.uniprot.org/uniprot/#_A2AS93-mappedCitation-22679284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22679284 |
| http://purl.uniprot.org/uniprot/#_B2RSC8-mappedCitation-22679284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22679284 |