| http://purl.uniprot.org/citations/22683125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22683125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22683125 | http://www.w3.org/2000/01/rdf-schema#comment | "Humans and mice deficient in the adaptor protein SAP (Sh2d1a) have a major defect in humoral immunity, resulting from a lack of T cell help for B cells. The role of SAP in this process is incompletely understood. We found that deletion of receptor Ly108 (Slamf6) in CD4(+) T cells reversed the Sh2d1a(-/-) phenotype, eliminating the SAP requirement for germinal centers. This potent negative signaling by Ly108 required immunotyrosine switch motifs (ITSMs) and SHP-1 recruitment, resulting in high amounts of SHP-1 at the T cell:B cell synapse, limiting T cell:B cell adhesion. Ly108-negative signaling was important not only in CD4(+) T cells; we found that NKT cell differentiation was substantially restored in Slamf6(-/-)Sh2d1a(-/-) mice. The ability of SAP to regulate both positive and negative signals in T cells can explain the severity of SAP deficiency and highlights the importance of SAP and SHP-1 competition for Ly108 ITSM binding as a rheostat for the magnitude of T cell help to B cells."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2012.05.016"xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2012.05.016"xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Zhao F."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Zhao F."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Schwartzberg P.L."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Schwartzberg P.L."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Cannons J.L."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Cannons J.L."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Kageyama R."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Kageyama R."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Crotty S."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Crotty S."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Lao C."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Lao C."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Locci M."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Locci M."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Yusuf I."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/author | "Yusuf I."xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/22683125 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |