| http://purl.uniprot.org/citations/22683683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22683683 | http://www.w3.org/2000/01/rdf-schema#comment | "Cortical synapses have structural, molecular and functional heterogeneity; our knowledge regarding the relationship between their ultrastructural and functional parameters is still fragmented. Here we asked how the neurotransmitter release probability and presynaptic [Ca(2+)] transients relate to the ultrastructure of rat hippocampal glutamatergic axon terminals. Two-photon Ca(2+) imaging-derived optical quantal analysis and correlated electron microscopic reconstructions revealed a tight correlation between the release probability and the active-zone area. Peak amplitude of [Ca(2+)] transients in single boutons also positively correlated with the active-zone area. Freeze-fracture immunogold labeling revealed that the voltage-gated calcium channel subunit Cav2.1 and the presynaptic protein Rim1/2 are confined to the active zone and their numbers scale linearly with the active-zone area. Gold particles labeling Cav2.1 were nonrandomly distributed in the active zones. Our results demonstrate that the numbers of several active-zone proteins, including presynaptic calcium channels, as well as the number of docked vesicles and the release probability, scale linearly with the active-zone area."xsd:string |
| http://purl.uniprot.org/citations/22683683 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.3137"xsd:string |
| http://purl.uniprot.org/citations/22683683 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/22683683 | http://purl.uniprot.org/core/author | "Katona G."xsd:string |
| http://purl.uniprot.org/citations/22683683 | http://purl.uniprot.org/core/author | "Kulik A."xsd:string |
| http://purl.uniprot.org/citations/22683683 | http://purl.uniprot.org/core/author | "Holderith N."xsd:string |
| http://purl.uniprot.org/citations/22683683 | http://purl.uniprot.org/core/author | "Lorincz A."xsd:string |
| http://purl.uniprot.org/citations/22683683 | http://purl.uniprot.org/core/author | "Nusser Z."xsd:string |
| http://purl.uniprot.org/citations/22683683 | http://purl.uniprot.org/core/author | "Rozsa B."xsd:string |
| http://purl.uniprot.org/citations/22683683 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22683683 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/22683683 | http://purl.uniprot.org/core/pages | "988-997"xsd:string |
| http://purl.uniprot.org/citations/22683683 | http://purl.uniprot.org/core/title | "Release probability of hippocampal glutamatergic terminals scales with the size of the active zone."xsd:string |
| http://purl.uniprot.org/citations/22683683 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/22683683 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22683683 |
| http://purl.uniprot.org/citations/22683683 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22683683 |
| http://purl.uniprot.org/uniprot/P54282#attribution-9D14E65955D623413C67C742A786C33C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22683683 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JXK1-mappedCitation-22683683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22683683 |
| http://purl.uniprot.org/uniprot/#_P54282-mappedCitation-22683683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22683683 |
| http://purl.uniprot.org/uniprot/#_A0A8I6B516-mappedCitation-22683683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22683683 |
| http://purl.uniprot.org/uniprot/#_A0A8I5Y6Y2-mappedCitation-22683683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22683683 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZPG4-mappedCitation-22683683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22683683 |
| http://purl.uniprot.org/uniprot/#_Q2YS33-mappedCitation-22683683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22683683 |
| http://purl.uniprot.org/uniprot/#_Q2YS34-mappedCitation-22683683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22683683 |