| http://purl.uniprot.org/citations/22685328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22685328 | http://www.w3.org/2000/01/rdf-schema#comment | "VE-cadherin-mediated cell-cell junction weakening increases paracellular permeability in response to both angiogenic and inflammatory stimuli. Although Semaphorin 3A has emerged as one of the few known anti-angiogenic factors to exhibit pro-permeability activity, little is known about how it triggers vascular leakage. Here we report that Semaphorin 3A induced VE-cadherin serine phosphorylation and internalisation, cell-cell junction destabilisation, and loss of barrier integrity in brain endothelial cells. In addition, high-grade glioma-isolated tumour-initiating cells were found to secrete Semaphorin 3A, which promoted brain endothelial monolayer permeability. From a mechanistic standpoint, Semaphorin 3A impinged upon the basal activity of the serine phosphatase PP2A and disrupted PP2A interaction with VE-cadherin, leading to cell-cell junction disorganization and increased permeability. Accordingly, both pharmacological inhibition and siRNA-based knockdown of PP2A mimicked Semaphorin 3A effects on VE-cadherin. Hence, local Semaphorin 3A production impacts on the PP2A/VE-cadherin equilibrium and contributes to elevated vascular permeability."xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.108282"xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/author | "Kettler G."xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/author | "Dubois S."xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/author | "Auffray C."xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/author | "Dwyer J."xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/author | "Treps L."xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/author | "Chneiweiss H."xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/author | "Bidere N."xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/author | "Gavard J."xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/author | "Galan-Moya E.M."xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/author | "Hebda J.K."xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/author | "Le Guelte A."xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/pages | "4137-4146"xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/title | "Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation."xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/22685328 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22685328 |
| http://purl.uniprot.org/citations/22685328 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22685328 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG50-mappedCitation-22685328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22685328 |
| http://purl.uniprot.org/uniprot/#_D3Z2A7-mappedCitation-22685328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22685328 |
| http://purl.uniprot.org/uniprot/#_E9Q668-mappedCitation-22685328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22685328 |
| http://purl.uniprot.org/uniprot/#_A0A803Z7F8-mappedCitation-22685328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22685328 |