| http://purl.uniprot.org/citations/22687243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22687243 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein kinase B (AKT) and glycogen synthase kinase-3β (GSK-3β) are major components of insulin-AKT signaling that plays crucial roles in various types of tissue. Recent studies found that these two kinases are modified posttranslationally by O-GlcNAcylation. Here, we demonstrate that O-GlcNAcylation regulated phosphorylation/activation of AKT and GSK-3β in different manners in kidney HEK-293FT cells, but did not affect these two kinases in hepatic HepG2 cells. In neuronal cells, O-GlcNAcylation regulated phosphorylation of AKT negatively, but had no effect on GSK-3β. These results suggest protein-specific and cell type-specific regulation of AKT and GSK-3β by O-GlcNAcylation. Therefore, studies on the roles of AKT and GSK-3β O-GlcNAcylation should be done in a tissue- and cell type-specific manner."xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.05.063"xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://purl.uniprot.org/core/author | "Grundke-Iqbal I."xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://purl.uniprot.org/core/author | "Iqbal K."xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://purl.uniprot.org/core/author | "Gong C.X."xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://purl.uniprot.org/core/author | "Dai C.L."xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22687243 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://purl.uniprot.org/core/pages | "2443-2450"xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://purl.uniprot.org/core/title | "Diverse regulation of AKT and GSK-3beta by O-GlcNAcylation in various types of cells."xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://purl.uniprot.org/core/volume | "586"xsd:string |
| http://purl.uniprot.org/citations/22687243 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22687243 |
| http://purl.uniprot.org/citations/22687243 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22687243 |
| http://purl.uniprot.org/uniprot/#_D3Z783-mappedCitation-22687243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22687243 |
| http://purl.uniprot.org/uniprot/#_D3YYP9-mappedCitation-22687243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22687243 |
| http://purl.uniprot.org/uniprot/#_D3YXX3-mappedCitation-22687243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22687243 |
| http://purl.uniprot.org/uniprot/#_B3KVH4-mappedCitation-22687243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22687243 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3D6-mappedCitation-22687243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22687243 |
| http://purl.uniprot.org/uniprot/#_A0A338P6P8-mappedCitation-22687243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22687243 |
| http://purl.uniprot.org/uniprot/#_A0A3B3ITW1-mappedCitation-22687243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22687243 |