| http://purl.uniprot.org/citations/22689061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22689061 | http://www.w3.org/2000/01/rdf-schema#comment | "The Yes-associated protein (YAP) is a transcriptional factor involved in tissue development and tumorigenesis. Although YAP has been recognized as a key element of the Hippo signaling pathway, the mechanisms that regulate YAP activities remain to be fully characterized. In this study, we demonstrate that the non-receptor type protein tyrosine phosphatase 14 (PTPN14) functions as a negative regulator of YAP. We show that YAP forms a protein complex with PTPN14 through the WW domains of YAP and the PPXY motifs of PTPN14. In addition, PTPN14 inhibits YAP-mediated transcriptional activities. Knockdown of YAP sensitizes cancer cells to various anti-cancer agents, such as cisplatin, the EGFR tyrosine kinase inhibitor erlotinib and the small-molecule antagonist of survivin, S12. YAP-targeted modalities may be used in combination with other cancer drugs to achieve maximal therapeutic effects."xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2012.231"xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/author | "Kumagai T."xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/author | "Mizuno T."xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/author | "Suzuki E."xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/author | "Huang J.M."xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/author | "Greene M.I."xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/author | "Berezov A."xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/author | "Karlan B."xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/author | "Nagatomo I."xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/pages | "2220-2229"xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/title | "YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14."xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/22689061 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22689061 |
| http://purl.uniprot.org/citations/22689061 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22689061 |
| http://purl.uniprot.org/uniprot/#_A8K6H6-mappedCitation-22689061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22689061 |
| http://purl.uniprot.org/uniprot/#_B4DNZ0-mappedCitation-22689061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22689061 |
| http://purl.uniprot.org/uniprot/#_B4E2Y3-mappedCitation-22689061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22689061 |
| http://purl.uniprot.org/uniprot/#_E2J9M0-mappedCitation-22689061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22689061 |
| http://purl.uniprot.org/uniprot/#_P46937-mappedCitation-22689061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22689061 |