| http://purl.uniprot.org/citations/22689655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22689655 | http://www.w3.org/2000/01/rdf-schema#comment | "Little is known about quality control of proteins that aberrantly or persistently engage the endoplasmic reticulum (ER)-localized translocon en route to membrane localization or the secretory pathway. Hrd1 and Doa10, the primary ubiquitin ligases that function in ER-associated degradation (ERAD) in yeast, target distinct subsets of misfolded or otherwise abnormal proteins based primarily on degradation signal (degron) location. We report the surprising observation that fusing Deg1, a cytoplasmic degron normally recognized by Doa10, to the Sec62 membrane protein rendered the protein a Hrd1 substrate. Hrd1-dependent degradation occurred when Deg1-Sec62 aberrantly engaged the Sec61 translocon channel and underwent topological rearrangement. Mutations that prevent translocon engagement caused a reversion to Doa10-dependent degradation. Similarly, a variant of apolipoprotein B, a protein known to be cotranslocationally targeted for proteasomal degradation, was also a Hrd1 substrate. Hrd1 therefore likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the translocon."xsd:string |
| http://purl.uniprot.org/citations/22689655 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201203061"xsd:string |
| http://purl.uniprot.org/citations/22689655 | http://purl.uniprot.org/core/author | "Rubenstein E.M."xsd:string |
| http://purl.uniprot.org/citations/22689655 | http://purl.uniprot.org/core/author | "Swanson R."xsd:string |
| http://purl.uniprot.org/citations/22689655 | http://purl.uniprot.org/core/author | "Hochstrasser M."xsd:string |
| http://purl.uniprot.org/citations/22689655 | http://purl.uniprot.org/core/author | "Kreft S.G."xsd:string |
| http://purl.uniprot.org/citations/22689655 | http://purl.uniprot.org/core/author | "Greenblatt W."xsd:string |
| http://purl.uniprot.org/citations/22689655 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22689655 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22689655 | http://purl.uniprot.org/core/pages | "761-773"xsd:string |
| http://purl.uniprot.org/citations/22689655 | http://purl.uniprot.org/core/title | "Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase."xsd:string |
| http://purl.uniprot.org/citations/22689655 | http://purl.uniprot.org/core/volume | "197"xsd:string |
| http://purl.uniprot.org/citations/22689655 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22689655 |
| http://purl.uniprot.org/citations/22689655 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22689655 |
| http://purl.uniprot.org/uniprot/#_P40318-mappedCitation-22689655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22689655 |
| http://purl.uniprot.org/uniprot/#_Q08109-mappedCitation-22689655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22689655 |
| http://purl.uniprot.org/uniprot/#_P21825-mappedCitation-22689655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22689655 |
| http://purl.uniprot.org/uniprot/P40318 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22689655 |
| http://purl.uniprot.org/uniprot/P21825 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22689655 |
| http://purl.uniprot.org/uniprot/Q08109 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22689655 |