| http://purl.uniprot.org/citations/22689882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22689882 | http://www.w3.org/2000/01/rdf-schema#comment | "EWI motif-containing protein 2 (EWI-2) is a member of the Ig superfamily that links tetraspanin-enriched microdomains to the actin cytoskeleton. We found that EWI-2 colocalizes with CD3 and CD81 at the central supramolecular activation cluster of the T cell immune synapse. Silencing of the endogenous expression or overexpression of a cytoplasmic truncated mutant of EWI-2 in T cells increases IL-2 secretion upon Ag stimulation. Mass spectrometry experiments of pull-downs with the C-term intracellular domain of EWI-2 revealed the specific association of EWI-2 with the actin-binding protein α-actinin; this association was regulated by PIP2. α-Actinin regulates the immune synapse formation and is required for efficient T cell activation. We extended these observations to virological synapses induced by HIV and found that silencing of either EWI-2 or α-actinin-4 increased cell infectivity. Our data suggest that the EWI-2-α-actinin complex is involved in the regulation of the actin cytoskeleton at T cell immune and virological synapses, providing a link between membrane microdomains and the formation of polarized membrane structures involved in T cell recognition."xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1103708"xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/author | "Kolesnikova T.V."xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/author | "Alvarez S."xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/author | "Vazquez J."xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/author | "Sanchez-Madrid F."xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/author | "Rocha-Perugini V."xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/author | "Yanez-Mo M."xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/author | "Lopez-Martin S."xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/author | "Gordon-Alonso M."xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/author | "Ursa A."xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/author | "Perez-Hernandez D."xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/author | "Sala-Valdes M."xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/pages | "689-700"xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/title | "EWI-2 association with alpha-actinin regulates T cell immune synapses and HIV viral infection."xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://purl.uniprot.org/core/volume | "189"xsd:string |
| http://purl.uniprot.org/citations/22689882 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22689882 |
| http://purl.uniprot.org/citations/22689882 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22689882 |
| http://purl.uniprot.org/uniprot/#_A0A024R694-mappedCitation-22689882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22689882 |
| http://purl.uniprot.org/uniprot/#_A1L0V1-mappedCitation-22689882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22689882 |
| http://purl.uniprot.org/uniprot/#_B4DFY0-mappedCitation-22689882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22689882 |
| http://purl.uniprot.org/uniprot/#_B3KUX9-mappedCitation-22689882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22689882 |