| http://purl.uniprot.org/citations/22693456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22693456 | http://www.w3.org/2000/01/rdf-schema#comment | "Translational repression is often accompanied by mRNA degradation. In contrast, many mRNAs in germ cells and neurons are "stored" in the cytoplasm in a repressed but stable form. Unlike repression, the stabilization of these mRNAs is surprisingly little understood. A key player in Caenorhabditis elegans germ cell development is the STAR domain protein GLD-1. By genome-wide analysis of mRNA regulation in the germ line, we observed that GLD-1 has a widespread role in repressing translation but, importantly, also in stabilizing a sub-population of its mRNA targets. Additionally, these mRNAs appear to be stabilized by the DDX6-like RNA helicase CGH-1, which is a conserved component of germ granules and processing bodies. Because many GLD-1 and CGH-1 stabilized mRNAs encode factors important for the oocyte-to-embryo transition (OET), our findings suggest that the regulation by GLD-1 and CGH-1 serves two purposes. Firstly, GLD-1-dependent repression prevents precocious translation of OET-promoting mRNAs. Secondly, GLD-1- and CGH-1-dependent stabilization ensures that these mRNAs are sufficiently abundant for robust translation when activated during OET. In the absence of this protective mechanism, the accumulation of OET-promoting mRNAs, and consequently the oocyte-to-embryo transition, might be compromised."xsd:string |
| http://purl.uniprot.org/citations/22693456 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002742"xsd:string |
| http://purl.uniprot.org/citations/22693456 | http://purl.uniprot.org/core/author | "Scheckel C."xsd:string |
| http://purl.uniprot.org/citations/22693456 | http://purl.uniprot.org/core/author | "Ciosk R."xsd:string |
| http://purl.uniprot.org/citations/22693456 | http://purl.uniprot.org/core/author | "Gaidatzis D."xsd:string |
| http://purl.uniprot.org/citations/22693456 | http://purl.uniprot.org/core/author | "Wright J.E."xsd:string |
| http://purl.uniprot.org/citations/22693456 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22693456 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/22693456 | http://purl.uniprot.org/core/pages | "e1002742"xsd:string |
| http://purl.uniprot.org/citations/22693456 | http://purl.uniprot.org/core/title | "Genome-wide analysis of GLD-1-mediated mRNA regulation suggests a role in mRNA storage."xsd:string |
| http://purl.uniprot.org/citations/22693456 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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