| http://purl.uniprot.org/citations/22699903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22699903 | http://www.w3.org/2000/01/rdf-schema#comment | "During brain morphogenesis, the mechanisms through which the cell cycle machinery integrates with differentiation signals remain elusive. Here we show that the Rb/E2F pathway regulates key aspects of differentiation and migration through direct control of the Dlx1 and Dlx2 homeodomain proteins, required for interneuron specification. Rb deficiency results in a dramatic reduction of Dlx1 and Dlx2 gene expression manifested by loss of interneuron subtypes and severe migration defects in the mouse brain. The Rb/E2F pathway modulates Dlx1/Dlx2 regulation through direct interaction with a Dlx forebrain-specific enhancer, I12b, and the Dlx1/Dlx2 proximal promoter regions, through repressor E2F sites both in vitro and in vivo. In the absence of Rb, we demonstrate that repressor E2Fs inhibit Dlx transcription at the Dlx1/Dlx2 promoters and Dlx1/2-I12b enhancer to suppress differentiation. Our findings support a model whereby the cell cycle machinery not only controls cell division but also modulates neuronal differentiation and migration through direct regulation of the Dlx1/Dlx2 bigene cluster during embryonic development."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.1344-12.2012"xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/author | "Park D.S."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/author | "Slack R.S."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/author | "Blais A."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/author | "Kothary R."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/author | "Ghanem N."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/author | "De Repentigny Y."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/author | "Ekker M."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/author | "Julian L.M."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/author | "Svoboda D."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/author | "McClellan K.A."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/author | "Andrusiak M.G."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/author | "Al Lafi S.M."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/pages | "8219-8230"xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/title | "The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster."xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/22699903 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22699903 |
| http://purl.uniprot.org/citations/22699903 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22699903 |
| http://purl.uniprot.org/uniprot/#_E9Q9G5-mappedCitation-22699903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22699903 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM76-mappedCitation-22699903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22699903 |
| http://purl.uniprot.org/uniprot/#_D3Z1L8-mappedCitation-22699903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22699903 |