| http://purl.uniprot.org/citations/22701718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22701718 | http://www.w3.org/2000/01/rdf-schema#comment | "The dicistronic Drosophila stoned gene is involved in exocytosis and/or endocytosis of synaptic vesicles. Mutations in either stonedA or stonedB cause a severe disruption of neurotransmission in fruit flies. Previous studies have shown that the coiled-coil domain of the Stoned-A and the µ-homology domain of the Stoned-B protein can interact with the C2B domain of Synaptotagmin-1. However, very little is known about the mechanism of interaction between the Stoned proteins and the C2B domain of Synaptotagmin-1. Here we report that these interactions are increased in the presence of Ca(2+). The Ca(2+)-dependent interaction between the µ-homology domain of Stoned-B and C2B domain of Synaptotagmin-1 is affected by phospholipids. The C-terminal region of the C2B domain, including the tryptophan-containing motif, and the Ca(2+) binding loop region that modulate the Ca(2+)-dependent oligomerization, regulates the binding of the Stoned-A and Stoned-B proteins to the C2B domain. Stoned-B, but not Stoned-A, interacts with the Ca(2+)-binding loop region of C2B domain. The results indicate that Ca(2+)-induced self-association of the C2B domain regulates the binding of both Stoned-A and Stoned-B proteins to Synaptotagmin-1. The Stoned proteins may regulate sustainable neurotransmission in vivo by binding to Ca(2+)-bound Synaptotagmin-1 associated synaptic vesicles."xsd:string |
| http://purl.uniprot.org/citations/22701718 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0038822"xsd:string |
| http://purl.uniprot.org/citations/22701718 | http://purl.uniprot.org/core/author | "Angkawidjaja C."xsd:string |
| http://purl.uniprot.org/citations/22701718 | http://purl.uniprot.org/core/author | "Kelly L.E."xsd:string |
| http://purl.uniprot.org/citations/22701718 | http://purl.uniprot.org/core/author | "Soekmadji C."xsd:string |
| http://purl.uniprot.org/citations/22701718 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22701718 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22701718 | http://purl.uniprot.org/core/pages | "e38822"xsd:string |
| http://purl.uniprot.org/citations/22701718 | http://purl.uniprot.org/core/title | "Ca2+ regulates the Drosophila Stoned-A and Stoned-B proteins interaction with the C2B domain of Synaptotagmin-1."xsd:string |
| http://purl.uniprot.org/citations/22701718 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22701718 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22701718 |
| http://purl.uniprot.org/citations/22701718 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22701718 |
| http://purl.uniprot.org/uniprot/#_A4V4W0-mappedCitation-22701718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22701718 |
| http://purl.uniprot.org/uniprot/#_P21521-mappedCitation-22701718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22701718 |
| http://purl.uniprot.org/uniprot/#_Q24211-mappedCitation-22701718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22701718 |
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| http://purl.uniprot.org/uniprot/#_X2JCY4-mappedCitation-22701718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22701718 |
| http://purl.uniprot.org/uniprot/#_X2J979-mappedCitation-22701718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22701718 |
| http://purl.uniprot.org/uniprot/#_X2J4C1-mappedCitation-22701718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22701718 |
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| http://purl.uniprot.org/uniprot/Q24212 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22701718 |
| http://purl.uniprot.org/uniprot/X2JGF5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22701718 |