| http://purl.uniprot.org/citations/22705205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22705205 | http://www.w3.org/2000/01/rdf-schema#comment | "The anti-atherogenic cytokine, TGF-β, plays a key role during macrophage foam cell formation by modulating the expression of key genes involved in the control of cholesterol homeostasis. Unfortunately, the molecular mechanisms underlying these actions of TGF-β remain poorly understood. In this study we examine the effect of TGF-β on macrophage cholesterol homeostasis and delineate the role of Smads-2 and -3 during this process. Western blot analysis showed that TGF-β induces a rapid phosphorylation-dependent activation of Smad-2 and -3 in THP-1 and primary human monocyte-derived macrophages. Small interfering RNA-mediated knockdown of Smad-2/3 expression showed that the TGF-β-mediated regulation of key genes implicated in the uptake of modified low density lipoproteins and the efflux of cholesterol from foam cells was Smad-dependent. Additionally, through the use of virally delivered Smad-2 and/or Smad-3 short hairpin RNA, we demonstrate that TGF-β inhibits the uptake of modified LDL by macrophages through a Smad-dependent mechanism and that the TGF-β-mediated regulation of CD36, lipoprotein lipase and scavenger receptor-A gene expression was dependent on Smad-2. These studies reveal a crucial role for Smad signaling, particularly Smad-2, in the inhibition of foam cell formation by TGF-β through the regulation of expression of key genes involved in the control of macrophage cholesterol homeostasis."xsd:string |
| http://purl.uniprot.org/citations/22705205 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2012.06.002"xsd:string |
| http://purl.uniprot.org/citations/22705205 | http://purl.uniprot.org/core/author | "Ramji D.P."xsd:string |
| http://purl.uniprot.org/citations/22705205 | http://purl.uniprot.org/core/author | "Michael D.R."xsd:string |
| http://purl.uniprot.org/citations/22705205 | http://purl.uniprot.org/core/author | "Salter R.C."xsd:string |
| http://purl.uniprot.org/citations/22705205 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22705205 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/22705205 | http://purl.uniprot.org/core/pages | "1608-1616"xsd:string |
| http://purl.uniprot.org/citations/22705205 | http://purl.uniprot.org/core/title | "TGF-beta inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: a dominant role for Smad-2."xsd:string |
| http://purl.uniprot.org/citations/22705205 | http://purl.uniprot.org/core/volume | "1822"xsd:string |
| http://purl.uniprot.org/citations/22705205 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22705205 |
| http://purl.uniprot.org/citations/22705205 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22705205 |
| http://purl.uniprot.org/uniprot/#_B7Z5N5-mappedCitation-22705205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22705205 |
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| http://purl.uniprot.org/uniprot/#_Q15796-mappedCitation-22705205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22705205 |
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| http://purl.uniprot.org/uniprot/Q15796 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22705205 |
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| http://purl.uniprot.org/uniprot/Q7Z5E4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22705205 |
| http://purl.uniprot.org/uniprot/B7Z5N5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22705205 |