| http://purl.uniprot.org/citations/22705372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22705372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22705372 | http://www.w3.org/2000/01/rdf-schema#comment | "Telomerase is a ribonucleoprotein complex essential for maintenance of telomere DNA at linear chromosome ends. The catalytic core of Tetrahymena telomerase comprises a ternary complex of telomerase RNA (TER), telomerase reverse transcriptase (TERT), and the essential La family protein p65. NMR and crystal structures of p65 C-terminal domain and its complex with stem IV of TER reveal that RNA recognition is achieved by a combination of single- and double-stranded RNA binding, which induces a 105° bend in TER. The domain is a cryptic, atypical RNA recognition motif with a disordered C-terminal extension that forms an α helix in the complex necessary for hierarchical assembly of TERT with p65-TER. This work provides the first structural insight into biogenesis and assembly of TER with a telomerase-specific protein. Additionally, our studies define a structurally homologous domain (xRRM) in genuine La and LARP7 proteins and suggest a general mode of RNA binding for biogenesis of their diverse RNA targets."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.05.018"xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.05.018"xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Cascio D."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Cascio D."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Singh M."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Singh M."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Collins K."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Collins K."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Patel A."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Patel A."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Feigon J."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Feigon J."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Koo B.K."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/author | "Koo B.K."xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/pages | "16-26"xsd:string |
| http://purl.uniprot.org/citations/22705372 | http://purl.uniprot.org/core/pages | "16-26"xsd:string |