| http://purl.uniprot.org/citations/22705555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22705555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22705555 | http://www.w3.org/2000/01/rdf-schema#comment | "We earlier identified two CXCL8-like lineages in cyprinid fish, which are functional homologues of the mammalian CXCL8, but with diverged functions. We here investigated whether the carp IFN-γ-inducible CXCb gene, related to the mammalian CXCL9, -10 and -11 chemokines, was subject to a similar diversification. On the zebrafish genome, a cluster of seven CXCb genes was found on chromosome five. Analysis of the promoter of the zebrafish CXCb genes suggests a partially shared, but differential induction. A second CXCb gene, CXCb2, was identified in common carp by homology cloning. CXCb2 is constitutively expressed in immune-related tissues, predominantly in head kidney lymphocytes/monocytes. Interestingly, an induction of CXCb2 gene expression with recombinant carp IFN-γ2 and LPS was observed in macrophages and granulocytes. Finally, difference in sensitivity to LPS, and kinetics of CXCb1 and CXCb2 gene expression during zymosan-induced peritonitis, was observed. These results indicate a functional diversification for cyprinid CXCb chemokines, with functional homology to mammalian CXCL9-11."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.dci.2012.05.005"xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.dci.2012.05.005"xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "Levraud J.P."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "Levraud J.P."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "Boudinot P."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "Boudinot P."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "Scheer M."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "Scheer M."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "Lidy Verburg-van Kemenade B.M."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "Lidy Verburg-van Kemenade B.M."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "Chadzinska M."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "Chadzinska M."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "Derks W."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "Derks W."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "van der Aa L.M."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/author | "van der Aa L.M."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/name | "Dev. Comp. Immunol."xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/name | "Dev Comp Immunol"xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/pages | "243-253"xsd:string |
| http://purl.uniprot.org/citations/22705555 | http://purl.uniprot.org/core/pages | "243-253"xsd:string |