| http://purl.uniprot.org/citations/22706990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22706990 | http://www.w3.org/2000/01/rdf-schema#comment | "Knowledge about the magnitude of individual polymorphism is a critical part in understanding the complexity of comprehensive mismatching. HLA-B*44:09 differs from the highly frequent HLA-B*44:02 allele by amino acid exchanges at residues 77, 80, 81, 82 and 83. We aimed to identify the magnitude of these mismatches on the features of HLA-B*44:09 bound peptides since residues 77, 80 and 81 comprise part of the F pocket which determines sequence specificity at the pΩ position of the peptide. Using soluble HLA technology we determined >200 individual (nonduplicate) self-peptides from HLA-B*44:09 and compared their features with that of the published peptide features of HLA-B*44:02. Both alleles illustrate an anchor motif of E at p2. In contrast to the C-terminal peptide binding motif of B*44:02 (W, F, Y or L), B*44:09-derived peptides are restricted predominantly to L or F. The source of peptides for both alleles is identical (LCL 721.221 cells) allowing us to identify 23 shared peptides. The majority of these peptides however contained the restricted B*44:09 anchor motif of F or L at the pΩ position. Molecular modelling based on the B*44:02 structure highlights that the differences of the C-terminal peptide anchor between both alleles can be explained primarily by the B*44:02(81Ala) > B*44:09(81Leu) polymorphism which restricts the size of the amino acid that can be accommodated in the F pocket of B*44:09. These results highlight that every amino acid substitution has an impact of certain magnitude on the alleles function and demonstrate how surrounding residues orchestrate peptide specificity."xsd:string |
| http://purl.uniprot.org/citations/22706990 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00251-012-0625-1"xsd:string |
| http://purl.uniprot.org/citations/22706990 | http://purl.uniprot.org/core/author | "Blasczyk R."xsd:string |
| http://purl.uniprot.org/citations/22706990 | http://purl.uniprot.org/core/author | "Huyton T."xsd:string |
| http://purl.uniprot.org/citations/22706990 | http://purl.uniprot.org/core/author | "Bade-Doeding C."xsd:string |
| http://purl.uniprot.org/citations/22706990 | http://purl.uniprot.org/core/author | "Schumacher H."xsd:string |
| http://purl.uniprot.org/citations/22706990 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22706990 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
| http://purl.uniprot.org/citations/22706990 | http://purl.uniprot.org/core/pages | "663-668"xsd:string |
| http://purl.uniprot.org/citations/22706990 | http://purl.uniprot.org/core/title | "Residue 81 confers a restricted C-terminal peptide binding motif in HLA-B*44:09."xsd:string |
| http://purl.uniprot.org/citations/22706990 | http://purl.uniprot.org/core/volume | "64"xsd:string |
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