| http://purl.uniprot.org/citations/22710124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22710124 | http://www.w3.org/2000/01/rdf-schema#comment | "The BK channel is one of the most broadly expressed ion channels in mammals. In many tissues, the BK channel pore-forming α-subunit is associated to an auxiliary β-subunit that modulates the voltage- and Ca(2+)-dependent activation of the channel. Structural components present in β-subunits that are important for the physical association with the α-subunit are yet unknown. Here, we show through co-immunoprecipitation that the intracellular C-terminus, the second transmembrane domain (TM2) and the extracellular loop of the β2-subunit are dispensable for association with the α-subunit pointing transmembrane domain 1 (TM1) as responsible for the interaction. Indeed, the TOXCAT assay for transmembrane protein-protein interactions demonstrated for the first time that TM1 of the β2-subunit physically binds to the transmembrane S1 domain of the α-subunit."xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.05.066"xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/author | "Gonzalez C."xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/author | "Kundu P."xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/author | "Salazar M."xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/author | "Alioua A."xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/author | "Stefani E."xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/author | "Toro L."xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/author | "Latorre R."xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/author | "Morera F.J."xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/author | "Martinez A.D."xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/pages | "2287-2293"xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/title | "The first transmembrane domain (TM1) of beta2-subunit binds to the transmembrane domain S1 of alpha-subunit in BK potassium channels."xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://purl.uniprot.org/core/volume | "586"xsd:string |
| http://purl.uniprot.org/citations/22710124 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22710124 |
| http://purl.uniprot.org/citations/22710124 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22710124 |
| http://purl.uniprot.org/uniprot/#_A0A087WZL8-mappedCitation-22710124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22710124 |
| http://purl.uniprot.org/uniprot/#_D5MRH1-mappedCitation-22710124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22710124 |
| http://purl.uniprot.org/uniprot/#_A0A1W2PR56-mappedCitation-22710124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22710124 |
| http://purl.uniprot.org/uniprot/#_A0A1W2PR62-mappedCitation-22710124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22710124 |
| http://purl.uniprot.org/uniprot/#_A0A1W2PRN5-mappedCitation-22710124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22710124 |
| http://purl.uniprot.org/uniprot/#_A0A1W2PP94-mappedCitation-22710124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22710124 |