| http://purl.uniprot.org/citations/22715467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22715467 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphatidylinositol 4,5-bisphosphate (PIP₂) is best known as a plasma membrane-bound regulatory lipid. Although PIP₂ and phosphoinositide-modifying enzymes coexist in the nucleus, their nuclear roles remain unclear. We showed that inositol polyphosphate multikinase (IPMK), which functions both as an inositol kinase and as a phosphoinositide 3-kinase (PI3K), interacts with the nuclear receptor steroidogenic factor 1 (SF-1) and phosphorylates its bound ligand, PIP₂. In vitro studies showed that PIP₂ was not phosphorylated by IPMK if PIP₂ was displaced or blocked from binding to the large hydrophobic pocket of SF-1 and that the ability to phosphorylate PIP₂ bound to SF-1 was specific to IPMK and did not occur with type 1 p110 PI3Ks. IPMK-generated SF-1-PIP₃ (phosphatidylinositol 3,4,5-trisphosphate) was dephosphorylated by the lipid phosphatase PTEN. Consistent with the in vitro activities of IPMK and PTEN on SF-1-PIP(n), SF-1 transcriptional activity was reduced by silencing IPMK or overexpressing PTEN. This ability of lipid kinases and phosphatases to directly remodel and alter the activity of a non-membrane protein-lipid complex establishes a previously unappreciated pathway for promoting lipid-mediated signaling in the nucleus."xsd:string |
| http://purl.uniprot.org/citations/22715467 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.2003111"xsd:string |
| http://purl.uniprot.org/citations/22715467 | http://purl.uniprot.org/core/author | "Suzawa M."xsd:string |
| http://purl.uniprot.org/citations/22715467 | http://purl.uniprot.org/core/author | "Blind R.D."xsd:string |
| http://purl.uniprot.org/citations/22715467 | http://purl.uniprot.org/core/author | "Ingraham H.A."xsd:string |
| http://purl.uniprot.org/citations/22715467 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22715467 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |
| http://purl.uniprot.org/citations/22715467 | http://purl.uniprot.org/core/pages | "ra44"xsd:string |
| http://purl.uniprot.org/citations/22715467 | http://purl.uniprot.org/core/title | "Direct modification and activation of a nuclear receptor-PIP(2) complex by the inositol lipid kinase IPMK."xsd:string |
| http://purl.uniprot.org/citations/22715467 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/22715467 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22715467 |
| http://purl.uniprot.org/citations/22715467 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22715467 |
| http://purl.uniprot.org/uniprot/#_A0A1E1GJF0-mappedCitation-22715467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22715467 |
| http://purl.uniprot.org/uniprot/#_B3KUB1-mappedCitation-22715467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22715467 |
| http://purl.uniprot.org/uniprot/#_B6ZGU8-mappedCitation-22715467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22715467 |
| http://purl.uniprot.org/uniprot/#_F1DAM0-mappedCitation-22715467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22715467 |
| http://purl.uniprot.org/uniprot/#_F1D8R8-mappedCitation-22715467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22715467 |
| http://purl.uniprot.org/uniprot/#_Q13285-mappedCitation-22715467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22715467 |
| http://purl.uniprot.org/uniprot/#_L8ECB8-mappedCitation-22715467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22715467 |
| http://purl.uniprot.org/uniprot/#_Q6QGY2-mappedCitation-22715467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22715467 |
| http://purl.uniprot.org/uniprot/#_Q8NFU5-mappedCitation-22715467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22715467 |
| http://purl.uniprot.org/uniprot/F1DAM0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22715467 |
| http://purl.uniprot.org/uniprot/B6ZGU8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22715467 |
| http://purl.uniprot.org/uniprot/F1D8R8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22715467 |