| http://purl.uniprot.org/citations/22718199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22718199 | http://www.w3.org/2000/01/rdf-schema#comment | "A small proportion of human immunodeficiency virus-1 (HIV-1) infected individuals, termed HIV-1 controllers, suppress viral replication to very low levels in the absence of therapy. Genetic investigations of this phenotype have strongly implicated variation in the class I major histocompatibility complex (MHC) region as key to HIV-1 control. We collected sequence-based classical class I HLA genotypes at 4-digit resolution in HIV-1-infected African American controllers and progressors (n = 1107), and tested them for association with host control using genome-wide single nucleotide polymorphism data to account for population structure. Several classical alleles at HLA-B were associated with host control, including B*57:03 [odds ratio (OR) = 5.1; P= 3.4 × 10(-18)] and B*81:01 (OR = 4.8; P= 1.3 × 10(-9)). Analysis of variable amino acid positions demonstrates that HLA-B position 97 is the most significant association with host control in African Americans (omnibus P = 1.2 × 10(-21)) and explains the signal of several HLA-B alleles, including B*57:03. Within HLA-B, we also identified independent effects at position 116 (omnibus P= 2.8 × 10(-15)) in the canonical F pocket, position 63 in the B pocket (P= 1.5 × 10(-3)) and the non-pocket position 245 (P= 8.8 × 10(-10)), which is thought to influence CD8-binding kinetics. Adjusting for these HLA-B effects, there is evidence for residual association in the MHC region. These results underscore the key role of HLA-B in affecting HIV-1 replication, likely through the molecular interaction between HLA-B and viral peptides presented by infected cells, and suggest that sites outside the peptide-binding pocket also influence HIV-1 control."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/dds226"xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Campbell J."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Davis K."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Garcia E."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Agarwal S."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Haber S."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Johnson K.L."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Berger J."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Jia X."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Montgomery K."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Ostrowski M."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Rodes B."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Rodriguez M."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Schmidt W."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Zhao M."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Torres R."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Wheeler D.A."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "White D.J."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Heath S."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Brown J."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Hunt P."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Gupta N."xsd:string |
| http://purl.uniprot.org/citations/22718199 | http://purl.uniprot.org/core/author | "Lopez A.J."xsd:string |