DESCRIBE <http://purl.uniprot.org/citations/22719219>

Subject	Predicate	Object
http://purl.uniprot.org/citations/22719219	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22719219	http://www.w3.org/2000/01/rdf-schema#comment	" Objective The WNT signaling pathway effector gene TCF7L2 has been associated with an increased risk of type 2 diabetes. However, it remains unclear how this gene affects diabetic pathogenesis. The goal of this study was to investigate the effects of Tcf7l2 haploinsufficiency on metabolic phenotypes in mice. Experimental design Tcf7l2 knockout (Tcf7l⁻/⁻) mice were generated. Because of the early mortality of Tcf7l2⁻/⁻ mice, we characterized the metabolic phenotypes of heterozygous Tcf7l2⁺/⁻ mice in comparison to the wild-type controls. The mice were fed a normal chow diet or a high fat diet (HFD) for 9 weeks. Results The Tcf7l2⁺/⁻ mice showed significant differences from the wild-type mice with regards to body weight, fasting glucose and insulin levels. Tcf7l2⁺/⁻ mice displayed improved glucose tolerance. In the liver of Tcf7l2⁺/⁻ mice fed on the HFD, reduced lipogenesis and hepatic triglyceride levels were observed when compared with those of wild-type mice. Furthermore, the Tcf7l2⁺/⁻ mice fed on the HFD exhibited decreased peripheral fat deposition. Immunohistochemistry in mouse pancreatic islets showed that endogenous expression of Tcf7l2 was upregulated in the wild-type mice, but not in the Tcf7l2⁺/⁻ mice, after feeding with the HFD. However, the haploinsufficiency of Tcf7l2 in mouse pancreatic islets resulted in little changes in glucose-stimulated insulin secretion. Conclusion These results suggest that decreased expression of Tcf7l2 confers reduction of diabetic susceptibility in mice via regulation on the metabolism of glucose and lipid."xsd:string
http://purl.uniprot.org/citations/22719219	http://purl.org/dc/terms/identifier	"doi:10.7150/ijbs.4568"xsd:string
http://purl.uniprot.org/citations/22719219	http://purl.uniprot.org/core/author	"Lee J.H."xsd:string
http://purl.uniprot.org/citations/22719219	http://purl.uniprot.org/core/author	"Li Q."xsd:string
http://purl.uniprot.org/citations/22719219	http://purl.uniprot.org/core/author	"Yang H."xsd:string
http://purl.uniprot.org/citations/22719219	http://purl.uniprot.org/core/author	"Shu Y."xsd:string
http://purl.uniprot.org/citations/22719219	http://purl.uniprot.org/core/date	"2012"xsd:gYear
http://purl.uniprot.org/citations/22719219	http://purl.uniprot.org/core/name	"Int J Biol Sci"xsd:string
http://purl.uniprot.org/citations/22719219	http://purl.uniprot.org/core/pages	"791-801"xsd:string
http://purl.uniprot.org/citations/22719219	http://purl.uniprot.org/core/title	"Reduction in Tcf7l2 expression decreases diabetic susceptibility in mice."xsd:string
http://purl.uniprot.org/citations/22719219	http://purl.uniprot.org/core/volume	"8"xsd:string
http://purl.uniprot.org/citations/22719219	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/22719219
http://purl.uniprot.org/citations/22719219	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/22719219
http://purl.uniprot.org/uniprot/#_E9Q990-mappedCitation-22719219	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22719219
http://purl.uniprot.org/uniprot/#_D3YWT3-mappedCitation-22719219	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22719219
http://purl.uniprot.org/uniprot/#_D3Z1L0-mappedCitation-22719219	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22719219
http://purl.uniprot.org/uniprot/#_A0A0R4J1G0-mappedCitation-22719219	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22719219
http://purl.uniprot.org/uniprot/#_E9QQ89-mappedCitation-22719219	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22719219
http://purl.uniprot.org/uniprot/#_E9QQ90-mappedCitation-22719219	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22719219
http://purl.uniprot.org/uniprot/#_E9QQ91-mappedCitation-22719219	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22719219
http://purl.uniprot.org/uniprot/#_F6XQR1-mappedCitation-22719219	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22719219
http://purl.uniprot.org/uniprot/#_D3Z002-mappedCitation-22719219	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22719219
http://purl.uniprot.org/uniprot/#_F6WBK9-mappedCitation-22719219	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22719219
http://purl.uniprot.org/uniprot/#_F6WPX2-mappedCitation-22719219	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22719219