| http://purl.uniprot.org/citations/22719267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22719267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22719267 | http://www.w3.org/2000/01/rdf-schema#comment | "Cells respond to defects in mitochondrial function by activating signaling pathways that restore homeostasis. The mitochondrial peptide exporter HAF-1 and the bZip transcription factor ATFS-1 represent one stress response pathway that regulates the transcription of mitochondrial chaperone genes during mitochondrial dysfunction. Here, we report that GCN-2, an eIF2α kinase that modulates cytosolic protein synthesis, functions in a complementary pathway to that of HAF-1 and ATFS-1. During mitochondrial dysfunction, GCN-2-dependent eIF2α phosphorylation is required for development as well as the lifespan extension observed in Caenorhabditis elegans. Reactive oxygen species (ROS) generated from dysfunctional mitochondria are required for GCN-2-dependent eIF2α phosphorylation but not ATFS-1 activation. Simultaneous deletion of ATFS-1 and GCN-2 compounds the developmental defects associated with mitochondrial stress, while stressed animals lacking GCN-2 display a greater dependence on ATFS-1 and stronger induction of mitochondrial chaperone genes. These findings are consistent with translational control and stress-dependent chaperone induction acting in complementary arms of the UPR(mt)."xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002760"xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002760"xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/author | "Sun T."xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/author | "Sun T."xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/author | "Baker B.M."xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/author | "Baker B.M."xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/author | "Haynes C.M."xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/author | "Haynes C.M."xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/author | "Nargund A.M."xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/author | "Nargund A.M."xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/pages | "E1002760"xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/pages | "E1002760"xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/title | "Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2."xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/title | "Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2."xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/22719267 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22719267 |
| http://purl.uniprot.org/citations/22719267 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22719267 |