| http://purl.uniprot.org/citations/22723427 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22723427 | http://www.w3.org/2000/01/rdf-schema#comment | "Eph/ephrin signaling has been implicated in various types of key cancer-enhancing processes, like migration, proliferation, and angiogenesis. In medulloblastoma, invading tumor cells characteristically lead to early recurrence and a decreased prognosis. Based on kinase-activity profiling data published recently, we hypothesized a key role for the Eph/ephrin signaling system in medulloblastoma invasion. In primary medulloblastoma samples, a significantly higher expression of EphB2 and the ligand ephrin-B1 was observed compared with normal cerebellum. Furthermore, medulloblastoma cell lines showed high expression of EphA2, EphB2, and EphB4. Stimulation of medulloblastoma cells with ephrin-B1 resulted in a marked decrease in in vitro cell adhesion and an increase in the invasion capacity of cells expressing high levels of EphB2. The cell lines that showed an ephrin-B1-induced phenotype possessed increased levels of phosphorylated EphB2 and, to a lesser extent, EphB4 after stimulation. Knockdown of EphB2 expression by short hairpin RNA completely abolished ephrin ligand-induced effects on adhesion and migration. Analysis of signal transduction identified p38, Erk, and mTOR as downstream signaling mediators potentially inducing the ephrin-B1 phenotype. In conclusion, the observed deregulation of Eph/ephrin expression in medulloblastoma enhances the invasive phenotype, suggesting a potential role in local tumor cell invasion and the formation of metastases."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.org/dc/terms/identifier | "doi:10.1093/neuonc/nos130"xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/author | "Peppelenbosch M.P."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/author | "Hulleman E."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/author | "van Vuurden D.G."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/author | "den Dunnen W.F."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/author | "Garcia-Manero G."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/author | "Diks S.H."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/author | "Kamps W.A."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/author | "de Bont E.S."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/author | "Hoving E.W."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/author | "Scherpen F.J."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/author | "Kampen K.R."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/author | "Sikkema A.H."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/name | "Neuro Oncol"xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/pages | "1125-1135"xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/title | "EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion."xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/22723427 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22723427 |
| http://purl.uniprot.org/citations/22723427 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22723427 |
| http://purl.uniprot.org/uniprot/#_E2I6F7-mappedCitation-22723427 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22723427 |
| http://purl.uniprot.org/uniprot/#_B4DQP7-mappedCitation-22723427 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22723427 |