| http://purl.uniprot.org/citations/22727665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22727665 | http://www.w3.org/2000/01/rdf-schema#comment | "Translational control of mRNAs in dendrites is essential for certain forms of synaptic plasticity and learning and memory. CPEB is an RNA-binding protein that regulates local translation in dendrites. Here, we identify poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) as components of a dendritic CPEB-associated polyadenylation apparatus. Synaptic stimulation induces phosphorylation of CPEB, PARN expulsion from the ribonucleoprotein complex, and polyadenylation in dendrites. A screen for mRNAs whose polyadenylation is altered by Gld2 depletion identified >100 transcripts including one encoding NR2A, an NMDA receptor subunit. shRNA depletion studies demonstrate that Gld2 promotes and Ngd inhibits dendritic NR2A expression. Finally, shRNA-mediated depletion of Gld2 in vivo attenuates protein synthesis-dependent long-term potentiation (LTP) at hippocampal dentate gyrus synapses; conversely, Ngd depletion enhances LTP. These results identify a pivotal role for polyadenylation and the opposing effects of Gld2 and Ngd in hippocampal synaptic plasticity."xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.05.016"xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/author | "Shin J."xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/author | "Takeuchi K."xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/author | "Richter J.D."xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/author | "Udagawa T."xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/author | "Bassell G.J."xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/author | "Zukin R.S."xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/author | "Lorenz L.J."xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/author | "Swanger S.A."xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/author | "Nalavadi V."xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/pages | "253-266"xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/title | "Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex."xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/22727665 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22727665 |
| http://purl.uniprot.org/citations/22727665 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22727665 |
| http://purl.uniprot.org/uniprot/P0C279#attribution-4A330354CCFCEBF3D49DD8A0E23F3E58 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22727665 |
| http://purl.uniprot.org/uniprot/Q5U315#attribution-4A330354CCFCEBF3D49DD8A0E23F3E58 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22727665 |
| http://purl.uniprot.org/uniprot/A6KGY5#attribution-4A330354CCFCEBF3D49DD8A0E23F3E58 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22727665 |
| http://purl.uniprot.org/uniprot/A0A8I6ALQ0#attribution-4A330354CCFCEBF3D49DD8A0E23F3E58 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22727665 |
| http://purl.uniprot.org/uniprot/A0A0G2JZ98#attribution-4A330354CCFCEBF3D49DD8A0E23F3E58 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22727665 |