| http://purl.uniprot.org/citations/22728827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22728827 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular mechanisms by which receptors regulate the Ras Binding Domains of the PIP3-generating, class I PI3Ks remain poorly understood, despite their importance in a range of biological settings, including tumorigenesis, activation of neutrophils by pro-inflammatory mediators, chemotaxis of Dictyostelium and cell growth in Drosophila. We provide evidence that G protein-coupled receptors (GPCRs) can stimulate PLCb2/b3 and diacylglycerol-dependent activation of the RasGEF, RasGRP4 in neutrophils. The genetic loss of RasGRP4 phenocopies knock-in of a Ras-insensitive version of PI3Kc in its effects on PI3Kc-dependent PIP3 accumulation, PKB activation, chemokinesis and reactive oxygen species (ROS) formation. These results establish a new mechanism by which GPCRs can stimulate Ras, and the broadly important principle that PLCs can control activation of class I PI3Ks."xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2012.167"xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/author | "Davidson K."xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/author | "Pan D."xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/author | "Niewczas I."xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/author | "Anderson K.E."xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/author | "Lecureuil C."xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/author | "Guillou H."xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/author | "Stephens L."xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/author | "Suire S."xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/author | "Damoulakis G."xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/author | "Jonathan Clark"xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/author | "Phillip T Hawkins"xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/pages | "3118-3129"xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/title | "GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4."xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/22728827 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22728827 |
| http://purl.uniprot.org/citations/22728827 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22728827 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVP1-mappedCitation-22728827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22728827 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVV6-mappedCitation-22728827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22728827 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW33-mappedCitation-22728827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22728827 |
| http://purl.uniprot.org/uniprot/#_E0CZ06-mappedCitation-22728827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22728827 |