| http://purl.uniprot.org/citations/22729085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22729085 | http://www.w3.org/2000/01/rdf-schema#comment | "Defects in stem cell renewal or progenitor cell expansion underlie ageing-related diseases such as osteoporosis. Yet much remains unclear about the mechanisms regulating progenitor expansion. Here we show that the tyrosine kinase c-Abl plays an important role in osteoprogenitor expansion. c-Abl interacts with and phosphorylates BMPRIA and the phosphorylation differentially influences the interaction of BMPRIA with BMPRII and the Tab1-Tak1 complex, leading to uneven activation of Smad1/5/8 and Erk1/2, the canonical and non-canonical BMP pathways that direct the expression of p16(INK4a). c-Abl deficiency shunts BMP signalling from Smad1/5/8 to Erk1/2, leading to p16(INK4a) upregulation and osteoblast senescence. Mouse genetic studies revealed that p16(INK4a) controls mesenchymal stem cell maintenance and osteoblast expansion and mediates the effects of c-Abl deficiency on osteoblast expansion and bone formation. These findings identify c-Abl as a regulator of BMP signalling pathways and uncover a role for c-Abl in p16(INK4a) expression and osteoprogenitor expansion."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2528"xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Chen G.Q."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Xia L."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "He L."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Ma G."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Goff S.P."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Boast S."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Leong W.F."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Chen Y.G."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Mishina Y."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Jia D."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Yeh J."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Chau J.F."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/author | "Kua H.Y."xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/pages | "727-737"xsd:string |
| http://purl.uniprot.org/citations/22729085 | http://purl.uniprot.org/core/title | "c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression."xsd:string |