http://purl.uniprot.org/citations/22730074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/22730074 | http://www.w3.org/2000/01/rdf-schema#comment | "UnlabelledGlutamatergic function is one of the major hypotheses for schizophrenia. Within the glutamate system, the glutamate receptor ionotropic kainate-1 (GRIK1) gene is thought to be particularly involved in schizophrenia because of the reported reduction of GRIK1 in the dorsolateral prefrontal cortex of patients.ObjectiveWe examined single-nucleotide polymorphisms (SNPs) in the GRIK1 gene for possible association with schizophrenia.MethodsWe analyzed eight SNPs across the GRIK1 gene in 202 case-control pairs and 108 small nuclear families.ResultsFor the case-control study, we found nominal significant associations in the analysis of rs469472 (p = 0.028) and its haplotypes. In the family-based study, nominal significant association was also observed for rs469472 (p = 0.046), as well as rs455892 (p = 0.024). The marker rs469472 was associated with schizophrenia when we combined the case-control and family samples (p = 0.027). The association findings did not survive correction for multiple testing.ConclusionsBecause we observed similar association findings with marker rs469472 in two independent samples, further analyses in larger samples are warranted."xsd:string |
http://purl.uniprot.org/citations/22730074 | http://purl.org/dc/terms/identifier | "doi:10.1002/hup.2233"xsd:string |
http://purl.uniprot.org/citations/22730074 | http://purl.uniprot.org/core/author | "Kennedy J.L."xsd:string |
http://purl.uniprot.org/citations/22730074 | http://purl.uniprot.org/core/author | "Hirata Y."xsd:string |
http://purl.uniprot.org/citations/22730074 | http://purl.uniprot.org/core/author | "Lieberman J.A."xsd:string |
http://purl.uniprot.org/citations/22730074 | http://purl.uniprot.org/core/author | "Souza R.P."xsd:string |
http://purl.uniprot.org/citations/22730074 | http://purl.uniprot.org/core/author | "Meltzer H.Y."xsd:string |
http://purl.uniprot.org/citations/22730074 | http://purl.uniprot.org/core/author | "Zai C.C."xsd:string |
http://purl.uniprot.org/citations/22730074 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
http://purl.uniprot.org/citations/22730074 | http://purl.uniprot.org/core/name | "Hum Psychopharmacol"xsd:string |
http://purl.uniprot.org/citations/22730074 | http://purl.uniprot.org/core/pages | "345-351"xsd:string |
http://purl.uniprot.org/citations/22730074 | http://purl.uniprot.org/core/title | "Association study of GRIK1 gene polymorphisms in schizophrenia: case-control and family-based studies."xsd:string |
http://purl.uniprot.org/citations/22730074 | http://purl.uniprot.org/core/volume | "27"xsd:string |
http://purl.uniprot.org/citations/22730074 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22730074 |
http://purl.uniprot.org/citations/22730074 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22730074 |
http://purl.uniprot.org/uniprot/#_E9PD61-mappedCitation-22730074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730074 |
http://purl.uniprot.org/uniprot/#_A0A8D9PH76-mappedCitation-22730074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730074 |
http://purl.uniprot.org/uniprot/#_B7Z256-mappedCitation-22730074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730074 |
http://purl.uniprot.org/uniprot/#_B7Z3V7-mappedCitation-22730074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730074 |
http://purl.uniprot.org/uniprot/#_P39086-mappedCitation-22730074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730074 |
http://purl.uniprot.org/uniprot/#_E7ENK3-mappedCitation-22730074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730074 |
http://purl.uniprot.org/uniprot/#_E7EPY9-mappedCitation-22730074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730074 |
http://purl.uniprot.org/uniprot/#_Q71UA3-mappedCitation-22730074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730074 |
http://purl.uniprot.org/uniprot/#_Q9UNN1-mappedCitation-22730074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730074 |