| http://purl.uniprot.org/citations/22730326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22730326 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphatase plays a crucial role in determining cellular fate by inactivating its substrate kinase, but it is not known whether a kinase can vice versa phosphorylate its phosphatase to execute this function. Protein-tyrosine phosphatase H1 (PTPH1) is a specific phosphatase of p38γ mitogen-activated protein kinase (MAPK) through PDZ binding, and here, we show that p38γ is also a PTPH1 kinase through which it executes its oncogenic activity and regulates stress response. PTPH1 was identified as a substrate of p38γ by unbiased proteomic analysis, and its resultant phosphorylation at Ser-459 occurs in vitro and in vivo through their complex formation. Genetic and pharmacological analyses showed further that Ser-459 phosphorylation is directly regulated by Ras signaling and is important for Ras, p38γ, and PTPH1 oncogenic activity. Moreover, experiments with physiological stimuli revealed a novel stress pathway from p38γ to PTPH1/Ser-459 phosphorylation in regulating cell growth and cell death by a mechanism dependent on cellular environments but independent of canonical MAPK activities. These results thus reveal a new mechanism by which a MAPK regulates Ras oncogenesis and stress response through directly phosphorylating its phosphatase."xsd:string |
| http://purl.uniprot.org/citations/22730326 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.335794"xsd:string |
| http://purl.uniprot.org/citations/22730326 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/22730326 | http://purl.uniprot.org/core/author | "Hou S."xsd:string |
| http://purl.uniprot.org/citations/22730326 | http://purl.uniprot.org/core/author | "Qi X."xsd:string |
| http://purl.uniprot.org/citations/22730326 | http://purl.uniprot.org/core/author | "Suresh P.S."xsd:string |
| http://purl.uniprot.org/citations/22730326 | http://purl.uniprot.org/core/author | "Mirza S.P."xsd:string |
| http://purl.uniprot.org/citations/22730326 | http://purl.uniprot.org/core/author | "Lepp A."xsd:string |
| http://purl.uniprot.org/citations/22730326 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22730326 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22730326 | http://purl.uniprot.org/core/pages | "27895-27905"xsd:string |
| http://purl.uniprot.org/citations/22730326 | http://purl.uniprot.org/core/title | "p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response."xsd:string |
| http://purl.uniprot.org/citations/22730326 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/22730326 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22730326 |
| http://purl.uniprot.org/citations/22730326 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22730326 |
| http://purl.uniprot.org/uniprot/#_A8K155-mappedCitation-22730326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730326 |
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| http://purl.uniprot.org/uniprot/#_B7Z274-mappedCitation-22730326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730326 |
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| http://purl.uniprot.org/uniprot/#_B3KUV9-mappedCitation-22730326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730326 |
| http://purl.uniprot.org/uniprot/#_B7Z8K9-mappedCitation-22730326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730326 |
| http://purl.uniprot.org/uniprot/#_B7Z948-mappedCitation-22730326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22730326 |
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