| http://purl.uniprot.org/citations/22732358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22732358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22732358 | http://www.w3.org/2000/01/rdf-schema#comment | "The FAM20 family of secreted proteins consists of three members (FAM20A, FAM20B, and FAM20C) recently linked to developmental disorders suggesting roles for FAM20 proteins in modulating biomineralization processes. The authors report here findings in knockout mice having null mutations affecting each of the three FAM20 proteins. Both Fam20a and Fam20c null mice survived to adulthood and showed biomineralization defects. Fam20b (-/-) embryos showed severe stunting and increased mortality at E13.5, although early lethality precluded detailed investigations. Physiologic calcification or biomineralization of extracellular matrices is a normal process in the development and functioning of various tissues (eg, bones and teeth). The lesions that developed in teeth, bones, or blood vessels after functional deletion of either Fam20a or Fam20c support a significant role for their encoded proteins in modulating biomineralization processes. Severe amelogenesis imperfecta (AI) was present in both Fam20a and Fam20c null mice. In addition, Fam20a (-/-) mice developed disseminated calcifications of muscular arteries and intrapulmonary calcifications, similar to those of fetuin-A deficient mice, although they were normocalcemic and normophosphatemic, with normal dentin and bone. Fam20a gene expression was detected in ameloblasts, odontoblasts, and the parathyroid gland, with local and systemic effects suggesting both local and/or systemic effects for FAM20A. In contrast, Fam20c (-/-) mice lacked ectopic calcifications but were severely hypophosphatemic and developed notable lesions in both dentin and bone to accompany the AI. The bone and dentin lesions, plus the marked hypophosphatemia and elevated serum alkaline phosphatase and FGF23 levels, are indicative of autosomal recessive hypophosphatemic rickets/osteomalacia in Fam20c (-/-) mice."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.org/dc/terms/identifier | "doi:10.1177/0300985812453177"xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.org/dc/terms/identifier | "doi:10.1177/0300985812453177"xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Vogel P."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Vogel P."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Thiel M."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Thiel M."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Read R.W."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Read R.W."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Hansen G.M."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Hansen G.M."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Smith D.D."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Smith D.D."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Brommage R."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Brommage R."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Jeter-Jones S."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Jeter-Jones S."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Vance R.B."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Vance R.B."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Wronski T.J."xsd:string |
| http://purl.uniprot.org/citations/22732358 | http://purl.uniprot.org/core/author | "Wronski T.J."xsd:string |