| http://purl.uniprot.org/citations/22733810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22733810 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) represent small noncoding RNAs that play a role in many diseases, including diabetes. miRNAs target genes important for pancreas development, β-cell proliferation, insulin secretion, and exocytosis. Previously, we documented that microRNA-30d (miR-30d), one of miRNAs up-regulated by glucose, induces insulin gene expression in pancreatic β-cells. Here, we found that the induction of insulin production by overexpression of miR-30d is associated with increased expression of MafA, a β-cell-specific transcription factor. Of interest, overexpression of miR-30d prevented the reduction in both MafA and insulin receptor substrate 2 (IRS2) with TNF-α exposure. Moreover, we identified that mitogen-activated protein 4 kinase 4 (MAP4K4), a TNF-α-activated kinase, is a direct target of miR-30d. Overexpression of miR-30d protected β-cells against TNF-α suppression on both insulin transcription and insulin secretion through the down-regulation of MAP4K4 by the miR-30d. A decrease of miR-30d expression was observed in the islets of diabetic db/db mice, in which MAP4K4 expression level was elevated. Our data support the notion that miR-30d plays multiple roles in activating insulin transcription and protecting β-cell functions from impaired by proinflammatory cytokines and underscore the concept that miR-30d may represent a novel pharmacological target for diabetes intervention."xsd:string |
| http://purl.uniprot.org/citations/22733810 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.362632"xsd:string |
| http://purl.uniprot.org/citations/22733810 | http://purl.uniprot.org/core/author | "Tang X."xsd:string |
| http://purl.uniprot.org/citations/22733810 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/22733810 | http://purl.uniprot.org/core/author | "Mohan R."xsd:string |
| http://purl.uniprot.org/citations/22733810 | http://purl.uniprot.org/core/author | "Ozcan S."xsd:string |
| http://purl.uniprot.org/citations/22733810 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22733810 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22733810 | http://purl.uniprot.org/core/pages | "31155-31164"xsd:string |
| http://purl.uniprot.org/citations/22733810 | http://purl.uniprot.org/core/title | "MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic beta-cells."xsd:string |
| http://purl.uniprot.org/citations/22733810 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/22733810 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22733810 |
| http://purl.uniprot.org/citations/22733810 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22733810 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW53-mappedCitation-22733810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22733810 |
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| http://purl.uniprot.org/uniprot/#_A0A0A6YWR8-mappedCitation-22733810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22733810 |
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| http://purl.uniprot.org/uniprot/#_B7ZNR9-mappedCitation-22733810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22733810 |
| http://purl.uniprot.org/uniprot/#_P97820-mappedCitation-22733810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22733810 |
| http://purl.uniprot.org/uniprot/#_Q3UTY9-mappedCitation-22733810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22733810 |
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| http://purl.uniprot.org/uniprot/A0A0A6YW53 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22733810 |