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| http://purl.uniprot.org/citations/22735594 | http://www.w3.org/2000/01/rdf-schema#comment | "Dermokine-β is abundant in stratified epithelia and in differentiating cultured keratinocytes. In this study, we investigated the role of dermokine-β in differentiation of keratinocytes. Treatment of keratinocytes or skin tumor cells with dermokine-β attenuated phosphorylation of extracellular-signal-regulated kinase (ERK). Exposure of cells to dermokine-β, as well as its carboxyl-terminus domain peptide, interrupted phosphorylation of ERK and stimulated dermokine gene expression. Inhibition of ERK signaling by its specific inhibitor also increased dermokine expression level. A combination of chemical cross-linking and immunoprecipitation, followed by proteomics analyses, identified glucose-regulated protein 78 (GRP78) as a dermokine-β-associated protein. Blockage of GRP78 expression by a specific siRNA abrogated actions of dermokine-β. These findings provide novel insights into the physiological significance of dermokine-β in the epidermis."xsd:string |
| http://purl.uniprot.org/citations/22735594 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.06.022"xsd:string |
| http://purl.uniprot.org/citations/22735594 | http://purl.uniprot.org/core/author | "Hasegawa M."xsd:string |
| http://purl.uniprot.org/citations/22735594 | http://purl.uniprot.org/core/author | "Saito K."xsd:string |
| http://purl.uniprot.org/citations/22735594 | http://purl.uniprot.org/core/author | "Mitsui S."xsd:string |
| http://purl.uniprot.org/citations/22735594 | http://purl.uniprot.org/core/author | "Yokoyama C."xsd:string |
| http://purl.uniprot.org/citations/22735594 | http://purl.uniprot.org/core/author | "Higashi K."xsd:string |
| http://purl.uniprot.org/citations/22735594 | http://purl.uniprot.org/core/author | "Tachibana T."xsd:string |
| http://purl.uniprot.org/citations/22735594 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22735594 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/22735594 | http://purl.uniprot.org/core/pages | "2300-2305"xsd:string |
| http://purl.uniprot.org/citations/22735594 | http://purl.uniprot.org/core/title | "Dermokine-beta impairs ERK signaling through direct binding to GRP78."xsd:string |
| http://purl.uniprot.org/citations/22735594 | http://purl.uniprot.org/core/volume | "586"xsd:string |
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