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http://purl.uniprot.org/citations/22736280 | http://www.w3.org/2000/01/rdf-schema#comment | "N-acetylglucosaminyltransferase (GnT)-IV a is a key enzyme that catalyzes the formation of the GlcNAC β1-4 branch on the core structure of complex N-Glycans, which is the common substrate for other N-acetylglucosaminyltransferases, such as GnT-III and GnT-V. Our recent study indicates that the expression of GnT-IVa in Hca-F cells was much higher than that in Hepa1-6 cells, these two mouse hepatocarcinoma cell lines have high and no metastatic potential in lymph nodes respectively. To investigate the effects of GnT-IVa on the metastasis of hepatocarcinoma, exogenous GnT-IVa was introduced into Hepa1-6 cells, and on the other hand, the expression of GnT-IVa was down-regulated in Hca-F cells. The engineered overexpression of GnT-IVa in Hepa1-6 cells increased the antennary branches of complex N-glycans and reduced bisecting branches in vitro and in vivo, which leads to the increase in migration and metastatic capability of hepatocarcinoma cells. Conversely, down-regulated expression of GnT-IVa in Hca-F cells showed reduced tetra-antennary branches of N-Glycans, and significantly decreased the migration and metastatic capability. Furthermore, we found that the regulated GnT-IVa converts the heterogeneous N-glycosylated forms of CD147 in Hepa1-6 and Hca-F cells, and significantly changed the antennary oligosaccharide structures on CD147. These results suggest that GnT-IVa could be acting as a key role in migration and metastasis of mouse hepatocarcinoma cells through altering the glycosylation of CD147. These findings should be valuable in delineating the important function of GnT-IVa during the process of hepatocarcinoma growth and metastasis."xsd:string |
http://purl.uniprot.org/citations/22736280 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10719-012-9414-1"xsd:string |
http://purl.uniprot.org/citations/22736280 | http://purl.uniprot.org/core/author | "He J."xsd:string |
http://purl.uniprot.org/citations/22736280 | http://purl.uniprot.org/core/author | "Fan J."xsd:string |
http://purl.uniprot.org/citations/22736280 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
http://purl.uniprot.org/citations/22736280 | http://purl.uniprot.org/core/author | "Yu S."xsd:string |
http://purl.uniprot.org/citations/22736280 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
http://purl.uniprot.org/citations/22736280 | http://purl.uniprot.org/core/author | "Zheng W."xsd:string |
http://purl.uniprot.org/citations/22736280 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
http://purl.uniprot.org/citations/22736280 | http://purl.uniprot.org/core/name | "Glycoconj J"xsd:string |
http://purl.uniprot.org/citations/22736280 | http://purl.uniprot.org/core/pages | "323-334"xsd:string |
http://purl.uniprot.org/citations/22736280 | http://purl.uniprot.org/core/title | "N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147."xsd:string |
http://purl.uniprot.org/citations/22736280 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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