| http://purl.uniprot.org/citations/22736793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22736793 | http://www.w3.org/2000/01/rdf-schema#comment | "A fundamental aspect of skeletal myogenesis involves extensive rounds of cell fusion, in which individual myoblasts are incorporated into growing muscle fibers. Here we demonstrate that N-WASp, a ubiquitous nucleation-promoting factor of branched microfilament arrays, is an essential contributor to skeletal muscle-cell fusion in developing mouse embryos. Analysis both in vivo and in primary satellite-cell cultures, shows that disruption of N-WASp function does not interfere with the program of skeletal myogenic differentiation, and does not affect myoblast motility, morphogenesis and attachment capacity. N-WASp-deficient myoblasts, however, fail to fuse. Furthermore, our analysis suggests that myoblast fusion requires N-WASp activity in both partners of a fusing myoblast pair. These findings reveal a specific role for N-WASp during mammalian myogenesis. WASp-family elements appear therefore to act as universal mediators of the myogenic cell-cell fusion mechanism underlying formation of functional muscle fibers, in both vertebrate and invertebrate species."xsd:string |
| http://purl.uniprot.org/citations/22736793 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1116065109"xsd:string |
| http://purl.uniprot.org/citations/22736793 | http://purl.uniprot.org/core/author | "Snapper S.B."xsd:string |
| http://purl.uniprot.org/citations/22736793 | http://purl.uniprot.org/core/author | "Schejter E.D."xsd:string |
| http://purl.uniprot.org/citations/22736793 | http://purl.uniprot.org/core/author | "Shilo B.Z."xsd:string |
| http://purl.uniprot.org/citations/22736793 | http://purl.uniprot.org/core/author | "Tzahor E."xsd:string |
| http://purl.uniprot.org/citations/22736793 | http://purl.uniprot.org/core/author | "Umansky K.B."xsd:string |
| http://purl.uniprot.org/citations/22736793 | http://purl.uniprot.org/core/author | "Gruenbaum-Cohen Y."xsd:string |
| http://purl.uniprot.org/citations/22736793 | http://purl.uniprot.org/core/author | "Harel I."xsd:string |
| http://purl.uniprot.org/citations/22736793 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22736793 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/22736793 | http://purl.uniprot.org/core/pages | "11211-11216"xsd:string |
| http://purl.uniprot.org/citations/22736793 | http://purl.uniprot.org/core/title | "The actin regulator N-WASp is required for muscle-cell fusion in mice."xsd:string |
| http://purl.uniprot.org/citations/22736793 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/22736793 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22736793 |
| http://purl.uniprot.org/citations/22736793 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22736793 |
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| http://purl.uniprot.org/uniprot/#_Q3USR1-mappedCitation-22736793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22736793 |