| http://purl.uniprot.org/citations/22743648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22743648 | http://www.w3.org/2000/01/rdf-schema#comment | "Boundary Element Associated Factor-32 (BEAF-32) is an insulator protein predominantly found near gene promoters and thought to play a role in gene expression. We find that mutations in BEAF-32 are lethal, show loss of epithelial morphology in imaginal discs and cause neoplastic growth defects. To investigate the molecular mechanisms underlying this phenotype, we carried out a genome-wide analysis of BEAF-32 localization in wing imaginal disc cells. Mutation of BEAF-32 results in miss-regulation of 3850 genes by at least 1.5-fold, 794 of which are bound by this protein in wing imaginal cells. Up-regulated genes encode proteins involved in cell polarity, cell proliferation and cell differentiation. Among the down-regulated genes are those encoding components of the wingless pathway, which is required for cell differentiation. Miss-regulation of these genes explains the unregulated cell growth and neoplastic phenotypes observed in imaginal tissues of BEAF-32 mutants."xsd:string |
| http://purl.uniprot.org/citations/22743648 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2012.06.013"xsd:string |
| http://purl.uniprot.org/citations/22743648 | http://purl.uniprot.org/core/author | "Corces V.G."xsd:string |
| http://purl.uniprot.org/citations/22743648 | http://purl.uniprot.org/core/author | "Gurudatta B.V."xsd:string |
| http://purl.uniprot.org/citations/22743648 | http://purl.uniprot.org/core/author | "Ramos E."xsd:string |
| http://purl.uniprot.org/citations/22743648 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22743648 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/22743648 | http://purl.uniprot.org/core/pages | "124-132"xsd:string |
| http://purl.uniprot.org/citations/22743648 | http://purl.uniprot.org/core/title | "The BEAF insulator regulates genes involved in cell polarity and neoplastic growth."xsd:string |
| http://purl.uniprot.org/citations/22743648 | http://purl.uniprot.org/core/volume | "369"xsd:string |
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