| http://purl.uniprot.org/citations/22744333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22744333 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon regulatory factor (IRF)-1 is a nuclear transcription factor that induces inflammatory cytokine mediators and contributes to hepatic ischemia-reperfusion (I/R) injury. No strategies to mitigate IRF1-mediated liver damage exist. IRF2 is a structurally similar endogenous protein that competes with IRF1 for DNA binding sites in IRF-responsive target genes and acts as a competitive inhibitor. However, the role of IRF2 in hepatic injury during hypoxic or inflammatory conditions is unknown. We hypothesize that IRF2 overexpression may mitigate IRF1-mediated I/R damage. Endogenous IRF2 is basally expressed in normal livers and is mildly increased by ischemia alone. Overexpression of IRF2 protects against hepatic warm I/R injury. Furthermore, we demonstrate that IRF2 overexpression limits production of IRF1-dependent proinflammatory genes, such as IL-12, IFNβ, and inducible nitric oxide synthase, even in the presence of IRF1 induction. Additionally, isograft liver transplantation with IRF2 heterozygote knockout (IRF2(+/-)) donor grafts that have reduced endogenous IRF2 levels results in worse injury following cold I/R during murine orthotopic liver transplantation. These findings indicate that endogenous intrahepatic IRF2 protein is protective, because the IRF2-deficient liver donor grafts exhibited increased liver damage compared with the wild-type donor grafts. In summary, IRF2 overexpression protects against I/R injury by decreasing IRF1-dependent injury and may represent a novel therapeutic strategy."xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.00050.2012"xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/author | "Kimura S."xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/author | "Murase N."xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/author | "Nakao A."xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/author | "Cardinal J."xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/author | "Geller D.A."xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/author | "Evankovich J."xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/author | "Ueki S."xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/author | "Tsung A."xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/author | "Klune J.R."xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/author | "Dhupar R."xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/author | "Nace G."xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/name | "Am J Physiol Gastrointest Liver Physiol"xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/pages | "G666-73"xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/title | "Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury."xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://purl.uniprot.org/core/volume | "303"xsd:string |
| http://purl.uniprot.org/citations/22744333 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22744333 |
| http://purl.uniprot.org/citations/22744333 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22744333 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQW5-mappedCitation-22744333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22744333 |
| http://purl.uniprot.org/uniprot/#_A0A140LHP8-mappedCitation-22744333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22744333 |
| http://purl.uniprot.org/uniprot/#_A0A140LI82-mappedCitation-22744333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22744333 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ7-mappedCitation-22744333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22744333 |