| http://purl.uniprot.org/citations/22745058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22745058 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundThe spermatogonial transplantation experiment can be used as an unequivocal detection assay of spermatogenic stem cells (SSCs) in both a qualitative and quantitative manner, based on their regenerative capacity. In this study, the proliferative patterns and kinetics of donor-derived GFRα1-positive spermatogonia containing potential SSCs were examined during early colonization following spermatogonial transplantation.ResultsDonor-derived GFRα1-positive cells frequently formed several aggregates of A(al(aligned)) /morula-like structures in a single spermatogenic cell patch before and on day 14 post-transplant, indicating a possible involvement in the formation of a stable spermatogenic colony at 21 days post-transplant. The appearance of these A(al) /morula-like aggregates is positively correlated with regional, high-level expression of immunoreactive GDNF signals, a ligand for GFRα1, associated with colony expansion.ConclusionsThese data raise the hypothesis that regional GDNF signals regulate the balance between donor-derived A(al) -like cell aggregates and their differentiation in each small patch, which subsequently leads to further selection of survival colonies at later stages."xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.23824"xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/author | "Sato T."xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/author | "Kanai Y."xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/author | "Nagai R."xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/author | "Kanai-Azuma M."xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/author | "Tsunekawa N."xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/author | "Kishi K."xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/author | "Kurohmaru M."xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/author | "Aiyama Y."xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/author | "Shinomura M."xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/author | "Harikae K."xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/name | "Dev Dyn"xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/pages | "1374-1384"xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/title | "Dynamics of GFRalpha1-positive spermatogonia at the early stages of colonization in the recipient testes of W/Wnu male mice."xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://purl.uniprot.org/core/volume | "241"xsd:string |
| http://purl.uniprot.org/citations/22745058 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22745058 |
| http://purl.uniprot.org/citations/22745058 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22745058 |
| http://purl.uniprot.org/uniprot/#_A0A097BVN3-mappedCitation-22745058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22745058 |
| http://purl.uniprot.org/uniprot/#_D3YWL3-mappedCitation-22745058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22745058 |
| http://purl.uniprot.org/uniprot/#_A0A1C7ZN00-mappedCitation-22745058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22745058 |
| http://purl.uniprot.org/uniprot/#_A0A7R7T2G6-mappedCitation-22745058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22745058 |
| http://purl.uniprot.org/uniprot/#_A0A7R7YCD8-mappedCitation-22745058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22745058 |