| http://purl.uniprot.org/citations/22745374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22745374 | http://www.w3.org/2000/01/rdf-schema#comment | "The persistence of memory T lymphocytes confers lifelong protection from pathogens. Memory T cells survive and undergo homeostatic proliferation (HSP) in the absence of Ag, although the cell-intrinsic mechanisms by which cytokines drive the HSP of memory T cells are not well understood. In this study we report that lysosome stability limits the long-term maintenance of memory CD8(+) T cell populations. Serine protease inhibitor (Spi) 2A, an anti-apoptotic cytosolic cathepsin inhibitor, is induced by both IL-15 and IL-7. Mice deficient in Spi2A developed fewer memory phenotype CD44(hi)CD8(+) T cells with age, which underwent reduced HSP in the bone marrow. Spi2A was also required for the maintenance of central memory CD8(+) T cell populations after acute infection with lymphocytic choriomeningitis virus. Spi2A-deficient Ag-specific CD8(+) T cell populations declined more than wild-type competitors after viral infection, and they were eroded further after successive infections. Spi2A protected memory cells from lysosomal breakdown by inhibiting cathepsin B. The impaired maintenance of Spi2A-deficient memory CD8(+) T cells was rescued by concomitant cathepsin B deficiency, demonstrating that cathepsin B was a physiological target of Spi2A in memory CD8(+) T cell survival. Our findings support a model in which protection from lysosomal rupture through cytokine-induced expression of Spi2A determines the long-term persistence of memory CD8(+) T cells."xsd:string |
| http://purl.uniprot.org/citations/22745374 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1003406"xsd:string |
| http://purl.uniprot.org/citations/22745374 | http://purl.uniprot.org/core/author | "Ashton-Rickardt P.G."xsd:string |
| http://purl.uniprot.org/citations/22745374 | http://purl.uniprot.org/core/author | "Olson S.T."xsd:string |
| http://purl.uniprot.org/citations/22745374 | http://purl.uniprot.org/core/author | "Davis D.M."xsd:string |
| http://purl.uniprot.org/citations/22745374 | http://purl.uniprot.org/core/author | "Elder M."xsd:string |
| http://purl.uniprot.org/citations/22745374 | http://purl.uniprot.org/core/author | "Byrne S.M."xsd:string |
| http://purl.uniprot.org/citations/22745374 | http://purl.uniprot.org/core/author | "Aucher A."xsd:string |
| http://purl.uniprot.org/citations/22745374 | http://purl.uniprot.org/core/author | "Alyahya S."xsd:string |
| http://purl.uniprot.org/citations/22745374 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22745374 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22745374 | http://purl.uniprot.org/core/pages | "1133-1143"xsd:string |
| http://purl.uniprot.org/citations/22745374 | http://purl.uniprot.org/core/title | "Cathepsin B controls the persistence of memory CD8+ T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/22745374 | http://purl.uniprot.org/core/volume | "189"xsd:string |
| http://purl.uniprot.org/citations/22745374 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22745374 |
| http://purl.uniprot.org/citations/22745374 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22745374 |
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