| http://purl.uniprot.org/citations/22745741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22745741 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulation of iron homeostasis and the inflammatory response are tightly linked to protect the host from infection. Here we investigate how imbalanced systemic iron homeostasis in a murine disease model of hereditary hemochromatosis (Hfe(-/-) mice) affects the inflammatory responses of the lung. We induced acute pulmonary inflammation in Hfe(-/-) and wild-type mice by intratracheal instillation of 20 µg of lipopolysaccharide (LPS) and analyzed local and systemic inflammatory responses and iron-related parameters. We show that in Hfe(-/-) mice neutrophil recruitment to the bronchoalveolar space is attenuated compared to wild-type mice although circulating neutrophil numbers in the bloodstream were elevated to similar levels in Hfe(-/-) and wild-type mice. The underlying molecular mechanisms are likely multifactorial and include elevated systemic iron levels, alveolar macrophage iron deficiency and/or hitherto unexplored functions of Hfe in resident pulmonary cell types. As a consequence, pulmonary cytokine expression is out of balance and neutrophils fail to be recruited efficiently to the bronchoalveolar compartment, a process required to protect the host from infections. In conclusion, our findings suggest a novel role for Hfe and/or imbalanced iron homeostasis in the regulation of the inflammatory response in the lung and hereditary hemochromatosis."xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0039363"xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/author | "Benes V."xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/author | "Klingmueller U."xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/author | "Muckenthaler M.U."xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/author | "Mall M.A."xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/author | "Schaefer S.M."xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/author | "Stolte J."xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/author | "Benesova K."xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/author | "Vujic Spasic M."xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/author | "Baehr-Ivacevic T."xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/author | "Waldow K."xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/pages | "e39363"xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/title | "Hfe deficiency impairs pulmonary neutrophil recruitment in response to inflammation."xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22745741 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22745741 |
| http://purl.uniprot.org/citations/22745741 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22745741 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-22745741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22745741 |
| http://purl.uniprot.org/uniprot/#_P70387-mappedCitation-22745741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22745741 |
| http://purl.uniprot.org/uniprot/#_F7CW53-mappedCitation-22745741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22745741 |
| http://purl.uniprot.org/uniprot/#_P08905-mappedCitation-22745741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22745741 |