| http://purl.uniprot.org/citations/22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22747494 | http://www.w3.org/2000/01/rdf-schema#comment | "Human catalase forms a 240-kDa tetrameric complex and degrades H(2) O(2) in peroxisomes. Human catalase is targeted to peroxisomes by the interaction of its peroxisomal targeting signal type 1 (PTS1)-like KANL sequence with the cytosolic PTS1 receptor Pex5p. We show herein that human catalase tetramers are formed in the cytoplasm and that the expression of a PTS signal on each of the four subunits is not necessary for peroxisomal transport. We previously demonstrated that a Pex5p mutant defective in binding to Pex13p, designated Pex5p(Mut234), imports typical PTS1-type proteins but not catalase. This impaired catalase import is not rescued by replacing its C-terminal KANL sequence with a typical PTS1 sequence, SKL, indicating that the failure of catalase import in Mut234-expressing cells is not due to its weak PTS1. In contrast, several enzymatically inactive and monomeric mutants of catalase are efficiently imported in Mut234-expressing cells. Moreover, trimeric chloramphenicol acetyltransferase (CAT) harboring SKL is not imported in Pex5p(Mut234)-expressing cells, but CAT-SKL trimers are transported to peroxisomes in the wild-type cells. These findings suggest that the Pex5p-Pex13p interaction likely plays a pivotal role in the peroxisomal import of folded and oligomeric proteins."xsd:string |
| http://purl.uniprot.org/citations/22747494 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-0854.2012.01391.x"xsd:string |
| http://purl.uniprot.org/citations/22747494 | http://purl.uniprot.org/core/author | "Fujiki Y."xsd:string |
| http://purl.uniprot.org/citations/22747494 | http://purl.uniprot.org/core/author | "Otera H."xsd:string |
| http://purl.uniprot.org/citations/22747494 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22747494 | http://purl.uniprot.org/core/name | "Traffic"xsd:string |
| http://purl.uniprot.org/citations/22747494 | http://purl.uniprot.org/core/pages | "1364-1377"xsd:string |
| http://purl.uniprot.org/citations/22747494 | http://purl.uniprot.org/core/title | "Pex5p imports folded tetrameric catalase by interaction with Pex13p."xsd:string |
| http://purl.uniprot.org/citations/22747494 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/22747494 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22747494 |
| http://purl.uniprot.org/citations/22747494 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22747494 |
| http://purl.uniprot.org/uniprot/#_P0C024-mappedCitation-22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22747494 |
| http://purl.uniprot.org/uniprot/#_Q15067-mappedCitation-22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22747494 |
| http://purl.uniprot.org/uniprot/#_A8MXV4-mappedCitation-22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22747494 |
| http://purl.uniprot.org/uniprot/#_O14734-mappedCitation-22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22747494 |
| http://purl.uniprot.org/uniprot/#_O15228-mappedCitation-22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22747494 |
| http://purl.uniprot.org/uniprot/#_O15254-mappedCitation-22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22747494 |
| http://purl.uniprot.org/uniprot/#_P21549-mappedCitation-22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22747494 |
| http://purl.uniprot.org/uniprot/#_P39210-mappedCitation-22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22747494 |
| http://purl.uniprot.org/uniprot/#_Q13011-mappedCitation-22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22747494 |
| http://purl.uniprot.org/uniprot/#_Q14032-mappedCitation-22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22747494 |
| http://purl.uniprot.org/uniprot/#_O75874-mappedCitation-22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22747494 |
| http://purl.uniprot.org/uniprot/#_P14920-mappedCitation-22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22747494 |
| http://purl.uniprot.org/uniprot/#_P43155-mappedCitation-22747494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22747494 |