Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/22748606http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22748606http://www.w3.org/2000/01/rdf-schema#comment"

Background and aims

New biomarkers potentially improve clinical management of cardiovascular disease, but there are gaps in understanding their role during childhood. Adiponectin regulates metabolism and exerts anti-inflammatory/anti-atherogenic effects. The aim of the study was to evaluate circulating levels of adiponectin during postnatal growth and its relationship with Brain Natriuretic Peptide (BNP) in healthy children, a marker of cardiac function known to be increased in childhood.

Methods and results

Plasma adiponectin and BNP were measured in 131 healthy children divided into: 43 newborns (0-3 days), 29 neonates (4-30 days), 25 infants (1-12 months) and 34 children (1-12 years). A group of 33 healthy adult subjects (25-60 years) was also studied. Plasma adiponectin in the 131 children resulted significantly higher compared to adult subjects (p < 0.0001). The time-course of adiponectin suggests the design of three age-based intervals: the first until 1 month of age (median 29.07 μg/mL, 11.61-47.01 μg/mL 5°-95° percentiles), the second between 1 and 12 months of age (21.66 μg/mL, 8.83-59.81 μg/mL) and the third for age up to 12 years (13.81 μg/mL, 4.10-28.57 μg/mL). Both adiponectin and BNP exhibited the same trend of a progressive decrease during growth, showing a significant relationship (Spearman's rho = 0.403, p < 0.0001).

Conclusion

Adiponectin plasma levels in a healthy pediatric population vary as a function of age. Three reference intervals for adiponectin in pediatric subjects have been indicated. The relationship between adiponectin and BNP suggests that the age-dependent profile of circulating adiponectin could also be due to BNP."xsd:string
http://purl.uniprot.org/citations/22748606http://purl.org/dc/terms/identifier"doi:10.1016/j.numecd.2012.03.004"xsd:string
http://purl.uniprot.org/citations/22748606http://purl.uniprot.org/core/author"Cabiati M."xsd:string
http://purl.uniprot.org/citations/22748606http://purl.uniprot.org/core/author"Del Ry S."xsd:string
http://purl.uniprot.org/citations/22748606http://purl.uniprot.org/core/author"Giannessi D."xsd:string
http://purl.uniprot.org/citations/22748606http://purl.uniprot.org/core/author"Storti S."xsd:string
http://purl.uniprot.org/citations/22748606http://purl.uniprot.org/core/author"Murzi B."xsd:string
http://purl.uniprot.org/citations/22748606http://purl.uniprot.org/core/author"Caselli C."xsd:string
http://purl.uniprot.org/citations/22748606http://purl.uniprot.org/core/author"Prescimone T."xsd:string
http://purl.uniprot.org/citations/22748606http://purl.uniprot.org/core/author"Cantinotti M."xsd:string
http://purl.uniprot.org/citations/22748606http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/22748606http://purl.uniprot.org/core/name"Nutr Metab Cardiovasc Dis"xsd:string
http://purl.uniprot.org/citations/22748606http://purl.uniprot.org/core/pages"657-661"xsd:string
http://purl.uniprot.org/citations/22748606http://purl.uniprot.org/core/title"Relation between adiponectin and brain natriuretic peptide in healthy pediatric subjects: from birth through childhood."xsd:string
http://purl.uniprot.org/citations/22748606http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/22748606http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22748606
http://purl.uniprot.org/citations/22748606http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22748606
http://purl.uniprot.org/uniprot/#_A8K660-mappedCitation-22748606http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22748606
http://purl.uniprot.org/uniprot/#_B2R773-mappedCitation-22748606http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22748606
http://purl.uniprot.org/uniprot/#_Q15848-mappedCitation-22748606http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22748606
http://purl.uniprot.org/uniprot/#_P16860-mappedCitation-22748606http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22748606
http://purl.uniprot.org/uniprot/B2R773http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22748606
http://purl.uniprot.org/uniprot/A8K660http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22748606
http://purl.uniprot.org/uniprot/Q15848http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22748606
▶