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http://purl.uniprot.org/citations/22753649http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22753649http://www.w3.org/2000/01/rdf-schema#comment"

Objective

STAT3 and 4 are, among other factors, critical for the interleukin 12 (IL-12)-mediated Th1 response, for transfer of IL-23 signals, and for survival and expansion of Th17 cells. We investigated the association of STAT3 and STAT4 polymorphisms with serologically distinct subgroups of rheumatoid arthritis (RA).

Methods

A total of 41 single-nucleotide polymorphisms (SNP) within STAT3 and STAT1-STAT4 loci were investigated in a Swedish cohort of 2043 RA cases and 1115 controls. Nine of the associated SNP were tested in a Spanish cohort of 1223 RA cases and 1090 controls.

Results

Fourteen SNP in the STAT3 and STAT1-STAT4 loci were associated with anticitrullinated protein antibody (ACPA)-negative RA in the Swedish cohort. Three of the SNP in STAT4 and 2 SNP in STAT3 remained associated with ACPA-negative RA after considering the Spanish results. In addition, rs7574865 and rs10181656, in STAT4, were associated with ACPA-positive RA in the Swedish study. One of these SNP, rs7574865, showed a similar pattern of the association in serologically distinct subgroups of RA in a metaanalysis of all 7 published studies.

Conclusion

Our findings suggest that variants in STAT genes may contribute differentially to susceptibility to RA in seropositive and in seronegative patients."xsd:string
http://purl.uniprot.org/citations/22753649http://purl.org/dc/terms/identifier"doi:10.3899/jrheum.111284"xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/author"Gonzalez A."xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/author"Alfredsson L."xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/author"Padyukov L."xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/author"Clark J.D."xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/author"Ding B."xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/author"Klareskog L."xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/author"Dunussi-Joannopoulos K."xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/author"Gomez-Reino J.J."xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/author"Seddighzadeh M."xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/author"Ferreiro-Iglesias A."xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/name"J Rheumatol"xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/pages"1509-1516"xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/title"Variants within STAT genes reveal association with anticitrullinated protein antibody-negative rheumatoid arthritis in 2 European populations."xsd:string
http://purl.uniprot.org/citations/22753649http://purl.uniprot.org/core/volume"39"xsd:string
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