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| http://purl.uniprot.org/citations/22757771 | http://www.w3.org/2000/01/rdf-schema#comment | "The nematode Caenorhabditis elegans is an organism most recognized for forward and reverse genetic and functional genomic approaches. Proteomic analyses of DNA damage-induced apoptosis have not been shown because of a limited number of cells undergoing apoptosis. We applied mass spectrometry-based quantitative proteomics to evaluate protein changes induced by ionizing radiation (IR) in isolated C. elegans germlines. For this purpose, we used isobaric peptide termini labeling (IPTL) combined with the data analysis tool IsobariQ, which utilizes MS/MS spectra for relative quantification of peak pairs formed during fragmentation. Using stringent statistical critera, we identified 48 proteins to be significantly up- or down-regulated, most of which are part of a highly interconnected protein-protein interaction network dominated by proteins involved in translational control. RNA-mediated depletion of a selection of the IR-regulated proteins revealed that the conserved CAR-1/CGH-1/CEY-3 germline RNP complex acts as a novel negative regulator of DNA-damage induced apoptosis. Finally, a central role of nucleolar proteins in orchestrating these responses was confirmed as the H/ACA snRNP protein GAR-1 was required for IR-induced apoptosis in the C. elegans germline."xsd:string |
| http://purl.uniprot.org/citations/22757771 | http://purl.org/dc/terms/identifier | "doi:10.1021/pr300386z"xsd:string |
| http://purl.uniprot.org/citations/22757771 | http://purl.uniprot.org/core/author | "Thiede B."xsd:string |
| http://purl.uniprot.org/citations/22757771 | http://purl.uniprot.org/core/author | "Nilsen H."xsd:string |
| http://purl.uniprot.org/citations/22757771 | http://purl.uniprot.org/core/author | "Kassahun H."xsd:string |
| http://purl.uniprot.org/citations/22757771 | http://purl.uniprot.org/core/author | "Tomazella G.G."xsd:string |
| http://purl.uniprot.org/citations/22757771 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22757771 | http://purl.uniprot.org/core/name | "J Proteome Res"xsd:string |
| http://purl.uniprot.org/citations/22757771 | http://purl.uniprot.org/core/pages | "4277-4288"xsd:string |
| http://purl.uniprot.org/citations/22757771 | http://purl.uniprot.org/core/title | "Quantitative proteome analysis reveals RNA processing factors as modulators of ionizing radiation-induced apoptosis in the C. elegans germline."xsd:string |
| http://purl.uniprot.org/citations/22757771 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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