| http://purl.uniprot.org/citations/22761446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22761446 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we examine the roles of two isoforms of glycogen synthase kinase-3 (GSK-3), GSK-3α and GSK-3β, in skeletal development. Both isoforms were unphosphorylated and active in chondrocyte differentiation stages during SOX9 and type II collagen (COL2A1) expression. Although knock-out of both alleles of Gsk3a (Gsk3a(-/-)) or a single allele of Gsk3b (Gsk3b(+/-)) in mice did not significantly affect skeletal development, compound knock-out (Gsk3a(-/-);Gsk3b(+/-)) caused dwarfism with impairment of chondrocyte differentiation. GSK-3α and GSK-3β induced differentiation of cultured chondrocytes with functional redundancy in a cell-autonomous fashion, independently of the Wnt/β-catenin signal. Computational predictions followed by SOX9 and COL2A1 transcriptional assays identified RelA (NF-κB p65) as a key phosphorylation target of GSK-3. Among several phosphorylation residues in RelA, Thr-254 was identified as the critical phosphorylation site for GSK-3 that modulated chondrocyte differentiation. In conclusion, redundant functions of GSK-3α and GSK-3β through phosphorylation of RelA at Thr-254 play a crucial role in early stages of chondrocyte differentiation."xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.372086"xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/author | "Kawaguchi H."xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/author | "Hirata M."xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/author | "Ikeda T."xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/author | "Itoh S."xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/author | "Woodgett J.R."xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/author | "Chung U.I."xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/author | "Algul H."xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/author | "Schmid R.M."xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/author | "Ushita M."xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/pages | "29227-29236"xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/title | "GSK-3alpha and GSK-3beta proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/22761446 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22761446 |
| http://purl.uniprot.org/citations/22761446 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22761446 |
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| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-22761446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22761446 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-22761446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22761446 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-22761446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22761446 |
| http://purl.uniprot.org/uniprot/#_A4L9Q2-mappedCitation-22761446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22761446 |