| http://purl.uniprot.org/citations/22762377 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22762377 | http://www.w3.org/2000/01/rdf-schema#comment | "In the present study, we investigated the gene expression of IL-8 and MCP-1 in HaCaT keratinocytes in response to poly(I:C), a synthetic dsRNA analogon. Both gene inductions were found to be mediated by TLR3 and downstream signalling pathways. While poly(I:C) induced IL-8 gene expression was solely inhibited by the NF-κB inhibitor III, MCP-1 gene induction was also blocked by PKA, p38 MAPK and JAK-STAT inhibitors. Moreover, Brefeldin A, an inhibitor of the anterograde transport, suppressed MCP-1 but not IL-8 gene expression, indicating that poly(I:C)-induced cytokines are involved in the chemokine gene expression. Both chemokines were expressed in response to the pro-inflammatory cytokines TNFα and IL-1β; however, MCP-1 gene induction was also found in response to IFNγ. These data are indicative for distinct signalling pathways in the poly(I:C)-induced gene expression of IL-8 and MCP-1 in HaCaT keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/22762377 | http://purl.org/dc/terms/identifier | "doi:10.2174/187152812803251042"xsd:string |
| http://purl.uniprot.org/citations/22762377 | http://purl.uniprot.org/core/author | "Bode G."xsd:string |
| http://purl.uniprot.org/citations/22762377 | http://purl.uniprot.org/core/author | "Kerkhoff C."xsd:string |
| http://purl.uniprot.org/citations/22762377 | http://purl.uniprot.org/core/author | "Voss A."xsd:string |
| http://purl.uniprot.org/citations/22762377 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22762377 | http://purl.uniprot.org/core/name | "Inflamm Allergy Drug Targets"xsd:string |
| http://purl.uniprot.org/citations/22762377 | http://purl.uniprot.org/core/pages | "397-405"xsd:string |
| http://purl.uniprot.org/citations/22762377 | http://purl.uniprot.org/core/title | "Double-stranded RNA induces IL-8 and MCP-1 gene expression via TLR3 in HaCaT-keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/22762377 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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